| Biomarkers and vasospasm after aneurysmal subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 20380977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Subarachnoid hemorrhage from the rupture of a saccular aneurysm is a devastating neurological disease that has a high morbidity and mortality not only from the initial hemorrhage, but also from the delayed complications, such as cerebral vasospasm. Cerebral vasospasm can lead to delayed ischemic injury 1 to 2 weeks after the initial hemorrhage. Although the pathophysiology of vasospasm has been described for decades, the molecular basis remains poorly understood. With the many advances in the past decade in the development of sensitive molecular biological techniques, imaging, biochemical purification, and protein identification, new insights are beginning to reveal the etiology of vasospasm. These findings will not only help to identify markers of vasospasm and prognostic outcome, but will also yield potential therapeutic targets for the treatment of this disease. This review focuses on the methods available for the identification of biological markers of vasospasm and their limitations, the current understanding as to the utility and prognostic significance of identified biomarkers, the utility of these biomarkers in predicting vasospasm and outcome, and future directions of research in this field. |
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Authors:
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J Dedrick Jordan; Paul Nyquist |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Neurosurgery clinics of North America Volume: 21 ISSN: 1558-1349 ISO Abbreviation: Neurosurg. Clin. N. Am. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-12 Completed Date: 2010-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9008004 Medline TA: Neurosurg Clin N Am Country: United States |
Other Details:
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Languages: eng Pagination: 381-91 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Johns Hopkins School of Medicine, 600 North Wolfe Street, Meyer 8-140, Baltimore, MD 21287-7840, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers Cerebral Arteries / metabolism, physiopathology* Diagnosis, Differential Endothelial Cells / metabolism Humans Nerve Degeneration / metabolism, pathology, physiopathology Nerve Tissue Proteins / analysis, blood Subarachnoid Hemorrhage / complications* Vasculitis, Central Nervous System / diagnosis, metabolism, physiopathology Vasodilation / physiology Vasospasm, Intracranial / diagnosis*, etiology, physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Nerve Tissue Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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