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Biomarkers to Diagnose Early Arthritis in Patients With Psoriasis.
MedLine Citation:
PMID:  25429195     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Psoriatic arthritis is a potentially destructive, inflammatory joint disease that affects 20% to 30% of patients with psoriasis. Psoriasis precedes the onset of joint inflammation by approximately 10 years, providing a unique opportunity to intervene and prevent or delay onset of musculoskeletal manifestations. The emergence of sensitive imaging modalities and cellular biomarkers may facilitate early identification of patients with psoriasis who have subclinical joint disease and might help stratify patients with an early onset of arthritis.
METHODS: The translational studies described herein are focused on the development of cellular biomarkers identified with flow cytometry and cell culture techniques in patients with psoriasis and psoriatic arthritis.
RESULTS AND CONCLUSION: The combination of power Doppler ultrasound imaging and cellular biomarkers (ie, CD16 and dendritic cell specific transmembrane protein) to diagnose early psoriatic arthritis and to stratify patients with established psoriatic arthritis provides a new opportunity to optimize treatment outcomes in this potentially disabling disease.
Authors:
Ya-Hui Grace Chiu; Christopher T Ritchlin
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Psoriasis forum / National Psoriasis Foundation     Volume:  18     ISSN:  1089-3504     ISO Abbreviation:  Psoriasis Forum     Publication Date:  2012  
Date Detail:
Created Date:  2014-11-27     Completed Date:  -     Revised Date:  2014-11-28    
Medline Journal Info:
Nlm Unique ID:  9890949     Medline TA:  Psoriasis Forum     Country:  -    
Other Details:
Languages:  ENG     Pagination:  2-10     Citation Subset:  -    
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