Document Detail


Biomarkers and predictors of restorative therapy effects after stroke.
MedLine Citation:
PMID:  23299824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many restorative therapies that promote brain repair are under development. Stroke is very heterogeneous, highlighting the need to identify target populations and to understand intersubject differences in treatment response. Several neuroimaging measures have shown promise as biomarkers and predictors, including measures of structure and function, in gray matter and white matter. The choice of biomarker and predictor can differ with the content of therapy and with the population under study, for example, contralesional hemisphere measures may be of particular importance in patients with more severe injury. Studies of training effects in healthy subjects provide insights useful to brain repair. Limitations of published studies include a focus on chronic stroke, however the brain is most galvanized to respond to restorative therapies in the early days after stroke. Multimodal approaches might be the most robust approach for stratifying patients and so for optimizing prescription of restorative therapies after stroke.
Authors:
Erin Burke; Steven C Cramer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  13     ISSN:  1534-6293     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-09     Completed Date:  2013-06-24     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  329     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Markers
Brain / pathology,  physiopathology*
Humans
Neuroimaging
Recovery of Function / physiology*
Stroke / pathology,  physiopathology,  rehabilitation*
Grant Support
ID/Acronym/Agency:
R01 NS058755/NS/NINDS NIH HHS; R01 NS059909/NS/NINDS NIH HHS; UL1 RR031985/RR/NCRR NIH HHS; UL1 TR000153/TR/NCATS NIH HHS; UL1TR000153/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers
Comments/Corrections

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