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Biomarkers of oxidative stress and personalized treatment of pulmonary tuberculosis: emerging role of gamma-glutamyltransferase.
MedLine Citation:
PMID:  22611380     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Background. The objectives were (i) to evaluate the impact of acute pulmonary tuberculosis (PTB) and anti-TB therapy on the relationship between AST, ALT, and GGT levels in absence of conditions related to hepatotoxicity; (ii) to evaluate the rate and the time of alterations of AST, ALT, and GGT. Design and Methods. A prospective followup of 40 adults (21 males; mean age of 34.7 ± 5.8 years) with active PTB on initial phase and continuation phase anti-TB. Results. Only 3% (n = 1) developed a transient and benign ADR at day 30 without interruption of anti-TB treatment. Within normal ranges, GGT decreased significantly from day 0 to day 60, while AST and ALT increased significantly and respectively. During day 0-day 60, there was a significant, negative, and independent association between GGT and AST. Conclusion. The initial two months led to significant improvement of oxidative stress. Values of oxidative markers in normal ranges might predict low rate of ADR.
Authors:
Etienne Mokondjimobe; Benjamin Longo-Mbenza; Jean Akiana; Ulrich Oswald Ndalla; Regis Dossou-Yovo; Joseph Mboussa; Henri-Joseph Parra
Publication Detail:
Type:  Journal Article     Date:  2012-05-07
Journal Detail:
Title:  Advances in pharmacological sciences     Volume:  2012     ISSN:  1687-6342     ISO Abbreviation:  Adv Pharmacol Sci     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-21     Completed Date:  2012-08-23     Revised Date:  2013-02-28    
Medline Journal Info:
Nlm Unique ID:  101537654     Medline TA:  Adv Pharmacol Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465634     Citation Subset:  -    
Affiliation:
Faculty of Health Sciences, Anti-Tuberculosis Centre, National Laboratory of Public Health, Marien Ngouabi University, Brazzaville, Democratic Republic of Congo.
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