| Biomarkers of oxidative stress and personalized treatment of pulmonary tuberculosis: emerging role of gamma-glutamyltransferase. | |
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MedLine Citation:
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PMID: 22611380 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Background. The objectives were (i) to evaluate the impact of acute pulmonary tuberculosis (PTB) and anti-TB therapy on the relationship between AST, ALT, and GGT levels in absence of conditions related to hepatotoxicity; (ii) to evaluate the rate and the time of alterations of AST, ALT, and GGT. Design and Methods. A prospective followup of 40 adults (21 males; mean age of 34.7 ± 5.8 years) with active PTB on initial phase and continuation phase anti-TB. Results. Only 3% (n = 1) developed a transient and benign ADR at day 30 without interruption of anti-TB treatment. Within normal ranges, GGT decreased significantly from day 0 to day 60, while AST and ALT increased significantly and respectively. During day 0-day 60, there was a significant, negative, and independent association between GGT and AST. Conclusion. The initial two months led to significant improvement of oxidative stress. Values of oxidative markers in normal ranges might predict low rate of ADR. |
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Authors:
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Etienne Mokondjimobe; Benjamin Longo-Mbenza; Jean Akiana; Ulrich Oswald Ndalla; Regis Dossou-Yovo; Joseph Mboussa; Henri-Joseph Parra |
Publication Detail:
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Type: Journal Article Date: 2012-05-07 |
Journal Detail:
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Title: Advances in pharmacological sciences Volume: 2012 ISSN: 1687-6342 ISO Abbreviation: Adv Pharmacol Sci Publication Date: 2012 |
Date Detail:
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Created Date: 2012-05-21 Completed Date: 2012-08-23 Revised Date: 2013-02-28 |
Medline Journal Info:
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Nlm Unique ID: 101537654 Medline TA: Adv Pharmacol Sci Country: United States |
Other Details:
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Languages: eng Pagination: 465634 Citation Subset: - |
Affiliation:
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Faculty of Health Sciences, Anti-Tuberculosis Centre, National Laboratory of Public Health, Marien Ngouabi University, Brazzaville, Democratic Republic of Congo. |
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