| Biomarkers of myocardial injury after cardiac arrest or myocardial ischemia. | |
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MedLine Citation:
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PMID: 20036954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Outcomes of victims of cardiac arrest or acute myocardial ischemic events have improved with advances in medical therapy. Heart failure, however, remains a leading cause of morbidity and mortality after these conditions have occurred. Clinical features may be useful for predicting patients who are at risk of developing such complications, but they lack of sensitivity and specificity. Biomarkers have been therefore suggested as means to provide relevant prognostic information. The more commonly used biomarkers after cardiovascular ischemic events, including cardiac arrest, are creatin kinases and troponins. In addition, natriuretic peptides and C-reactive protein have gained great interest and now sufficient data has been collected such to justify their clinical applicability. Finally, several other novel biomarkers, to be used after resuscitation from cardiac arrest or more generally after a myocardial ischemic event, have been anticipated. Nevertheless, the "perfect" biomarker, able to provide diagnosis and prognosis with high sensitivity and specificity does not exit. A multimarker strategy that categorizes patients based on the number of elevated biomarkers at presentation is therefore suggested. |
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Authors:
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Giuseppe Ristagno; Cristina Santonocito; Yongqin Li; Giovanni Li Volti; Antonino Gullo |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-01-01 |
Journal Detail:
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Title: Frontiers in bioscience (Scholar edition) Volume: 2 ISSN: 1945-0524 ISO Abbreviation: Front Biosci (Schol Ed) Publication Date: 2010 |
Date Detail:
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Created Date: 2009-12-28 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101485241 Medline TA: Front Biosci (Schol Ed) Country: United States |
Other Details:
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Languages: eng Pagination: 373-91 Citation Subset: IM |
Affiliation:
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Weil Institute of Critical Care Medicine, 35100 Bob Hope DR, Rancho Mirage, California 92270, USA. gristag@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenomedullin
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metabolism Arginine Vasopressin / metabolism Biological Markers / metabolism* C-Reactive Protein / metabolism Cardiopulmonary Resuscitation / methods Creatine Kinase / metabolism Endothelin-1 / metabolism Heart Arrest / complications* Heart Failure / diagnosis*, etiology, physiopathology* Humans Immunity, Innate / physiology* Myocardial Ischemia / complications*, immunology Natriuretic Peptides / metabolism Serum Amyloid P-Component / metabolism Troponin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Endothelin-1; 0/Natriuretic Peptides; 0/Serum Amyloid P-Component; 0/Troponin; 113-79-1/Arginine Vasopressin; 148498-78-6/Adrenomedullin; 148591-49-5/PTX3 protein; 9007-41-4/C-Reactive Protein; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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