Document Detail


Biomarkers of myocardial fibrosis.
MedLine Citation:
PMID:  21423029     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Increased cardiac collagen deposition is observed in almost every cardiac disease and plays an important role in the deteriorating function of the diseased heart. Propeptides of procollagen type I and III, the two major collagen types in the heart, can be detected in circulation. While these propeptides reflect the collagen synthesis, also breakdown products of collagen and the matrix metalloproteinases, responsible for the breakdown of the extracellular matrix, can be detected in blood and are used for investigating the turnover of collagen. Clinical trials are performed in the last recent years to examine the usage of these biomarkers in a diagnostic or prognostic way in heart failure patients. This review aims to discuss the formation of fibrosis and studies investigating these biomarkers in heart failure are reviewed in the current article. In addition, it is conferred what the flaws are of translating these biomarker levels to the cardiac fibrosis formation and where we stand in using these biomarkers in clinics.
Authors:
Sanne de Jong; Toon A B van Veen; Jacques Mt de Bakker; Marc A Vos; Harold V M van Rijen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-17
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Department of Medical Physiology. Division Heart and Lungs, University Medical Center Utrecht, The Netherlands; 2Interuniversity Cardiology Institute of the Netherlands. Utrecht, The Netherlands.
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