Document Detail

Biomarkers of milk fat and the risk of myocardial infarction in men and women: a prospective, matched case-control study.
MedLine Citation:
PMID:  20484449     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: High intakes of saturated fat have been associated with cardiovascular disease, and milk fat is rich in saturated fat. OBJECTIVE: The objective of this study was to investigate the association between the serum milk fat biomarkers pentadecanoic acid (15:0), heptadecanoic acid (17:0), and their sum (15:0+17:0) and a first myocardial infarction (MI). DESIGN: The study design was a prospective case-control study nested within a large population-based cohort in Sweden. Included in the study were 444 cases (307 men) and 556 controls (308 men) matched on sex, age, date of examination, and geographic region. Clinical, anthropometric, biomarker fatty acid, physical activity, and dietary data were collected. The odds of a first MI were investigated by using conditional logistic regression. RESULTS: In women, proportions of milk fat biomarkers in plasma phospholipids were significantly higher (P < 0.05) in controls than in cases and were, in general, negatively, albeit weakly, correlated with risk factors for metabolic syndrome. The crude standardized odds ratios of becoming an MI case were 0.74 (95% CI: 0.58, 0.94) in women and 0.91 (95% CI: 0.77, 1.1) in men. After multivariable adjustment for confounders, the inverse association remained in both sexes and was significant in women. In agreement with biomarker data, quartiles of reported intake of cheese (men and women) and fermented milk products (men) were inversely related to a first MI (P for trend < 0.05 for all). CONCLUSIONS: Milk fat biomarkers were associated with a lower risk of developing a first MI, especially in women. This was partly confirmed in analysis of fermented milk and cheese intake. Components of metabolic syndrome were observed as potential intermediates for the risk relations.
Eva Warensjö; Jan-Håkan Jansson; Tommy Cederholm; Kurt Boman; Mats Eliasson; Göran Hallmans; Ingegerd Johansson; Per Sjögren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-19
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  92     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  194-202     Citation Subset:  AIM; IM    
Department of Public Health, Uppsala University, Uppsala, Sweden.
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MeSH Terms
Blood Pressure
Cohort Studies
Dietary Fats / adverse effects*
Educational Status
Middle Aged
Milk / adverse effects*
Models, Statistical
Myocardial Infarction / epidemiology*,  physiopathology
Odds Ratio
Patient Selection
Phospholipids / blood,  pharmacology
Reference Values
Risk Assessment
Risk Factors
Sex Characteristics
Smoking / epidemiology
Sweden / epidemiology
Reg. No./Substance:
0/Dietary Fats; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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