| Biomarkers for late-onset neonatal sepsis: cytokines and beyond. | |
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MedLine Citation:
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PMID: 20813273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute phase reactants, pro and antiinflammatory mediators including chemokines and cytokines, and cell-surface antigens are nonspecific biomarkers that have been extensively studied for the diagnosis and management of late-onset neonatal sepsis (LONS) and necrotizing enterocolitis. It is expected that the next generation of biomarkers and tests will be more specific, will pinpoint the precise disease entity, and will provide crucial information on the exact pathogen or category of microorganism and its antibiotic profile within hours of clinical presentation. Research on molecular pathogen detection and proteomic profiling has shown promising results. Academic-industry partnerships are vital for successful development of new diagnostic biomarkers for LONS, which are sensitive, inexpensive, fully automated, and easy to measure, allowing a quick turnaround time for clinical decision making. |
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Authors:
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Pak C Ng; Hugh S Lam |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinics in perinatology Volume: 37 ISSN: 1557-9840 ISO Abbreviation: Clin Perinatol Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501306 Medline TA: Clin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 599-610 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. pakcheungng@cuhk.edu.hk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Surface
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blood* Biological Markers / blood* C-Reactive Protein / metabolism* Cytokines / blood* Diagnosis, Differential Humans Infant, Newborn Sepsis / blood*, diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Surface; 0/Biological Markers; 0/Cytokines; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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