| Biomarkers of inflammation and endothelial dysfunction and risk of hypertension among Inner Mongolians in China. | |
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MedLine Citation:
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PMID: 19770776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We examined the association between plasma concentrations of high-sensitivity C-reactive protein, soluble intercellular adhesion molecule 1, soluble E-selectin, angiotensin II, renin activity and the risk of hypertension among 2589 study participants aged 20 years and older from Inner Mongolia, China. METHODS: Three blood pressure measurements were obtained using a standard mercury sphygmomanometer and hypertension was defined as blood pressure of at least 140/90 mmHg or use of antihypertensive medications. Overnight fasting blood samples were obtained to measure the biomarkers of endothelial dysfunction and inflammation. RESULTS: The average levels of high-sensitivity C-reactive protein (7.5 vs. 5.4 mg/l), soluble intercellular adhesion molecule 1 (339.4 vs. 322.6 ng/ml), soluble E-selectin (19.1 vs. 18.2 ng/ml), and angiotensin II (52.0 vs. 47.0 pg/ml) were significantly higher, whereas renin activity (1.3 vs. 1.5 mg/ml.h) was lower in hypertensive compared to normotensive participants (all P value <0.001). Compared to the lowest quartile, the multivariable-adjusted odds ratios (95% confidence interval) of hypertension for the highest quartile were 1.41 (1.06, 1.86) for high-sensitivity C-reactive protein, 1.93 (1.48, 2.53) for angiotensin II, and 0.70 (0.54, 0.91) for renin activity. CONCLUSION: Our study indicated that elevated plasma levels of high-sensitivity C-reactive protein and angiotensin II were positively and renin activity inversely associated with the risk of hypertension. These data suggest that inflammation and endothelial dysfunction may play a role in the cause of hypertension. |
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Authors:
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Yonghong Zhang; Angela M Thompson; Weijun Tong; Tan Xu; Jing Chen; Li Zhao; Tanika N Kelly; Chung-Shiuan Chen; Jiang He |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-03-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 35-40 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, Soochow University School of Radiation Medicine and Public Health, Suzhou, China. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Angiotensin II / blood Asian Continental Ancestry Group / ethnology* Biological Markers / analysis Blood Pressure Blood Proteins / analysis* C-Reactive Protein / analysis China / ethnology Cross-Sectional Studies E-Selectin / blood Endothelium, Vascular / metabolism*, physiopathology Female Humans Hypertension / blood, complications, ethnology* Inflammation / blood, complications, ethnology* Intercellular Adhesion Molecule-1 / blood Male Middle Aged Renin / blood Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Proteins; 0/E-Selectin; 11128-99-7/Angiotensin II; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-41-4/C-Reactive Protein; EC 3.4.23.15/Renin |
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