Document Detail

Biomarkers of inflammation and endothelial dysfunction and risk of hypertension among Inner Mongolians in China.
MedLine Citation:
PMID:  19770776     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We examined the association between plasma concentrations of high-sensitivity C-reactive protein, soluble intercellular adhesion molecule 1, soluble E-selectin, angiotensin II, renin activity and the risk of hypertension among 2589 study participants aged 20 years and older from Inner Mongolia, China. METHODS: Three blood pressure measurements were obtained using a standard mercury sphygmomanometer and hypertension was defined as blood pressure of at least 140/90 mmHg or use of antihypertensive medications. Overnight fasting blood samples were obtained to measure the biomarkers of endothelial dysfunction and inflammation. RESULTS: The average levels of high-sensitivity C-reactive protein (7.5 vs. 5.4 mg/l), soluble intercellular adhesion molecule 1 (339.4 vs. 322.6 ng/ml), soluble E-selectin (19.1 vs. 18.2 ng/ml), and angiotensin II (52.0 vs. 47.0 pg/ml) were significantly higher, whereas renin activity (1.3 vs. 1.5 mg/ml.h) was lower in hypertensive compared to normotensive participants (all P value <0.001). Compared to the lowest quartile, the multivariable-adjusted odds ratios (95% confidence interval) of hypertension for the highest quartile were 1.41 (1.06, 1.86) for high-sensitivity C-reactive protein, 1.93 (1.48, 2.53) for angiotensin II, and 0.70 (0.54, 0.91) for renin activity. CONCLUSION: Our study indicated that elevated plasma levels of high-sensitivity C-reactive protein and angiotensin II were positively and renin activity inversely associated with the risk of hypertension. These data suggest that inflammation and endothelial dysfunction may play a role in the cause of hypertension.
Yonghong Zhang; Angela M Thompson; Weijun Tong; Tan Xu; Jing Chen; Li Zhao; Tanika N Kelly; Chung-Shiuan Chen; Jiang He
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  28     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-40     Citation Subset:  IM    
Department of Epidemiology, Soochow University School of Radiation Medicine and Public Health, Suzhou, China.
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MeSH Terms
Angiotensin II / blood
Asian Continental Ancestry Group / ethnology*
Biological Markers / analysis
Blood Pressure
Blood Proteins / analysis*
C-Reactive Protein / analysis
China / ethnology
Cross-Sectional Studies
E-Selectin / blood
Endothelium, Vascular / metabolism*,  physiopathology
Hypertension / blood,  complications,  ethnology*
Inflammation / blood,  complications,  ethnology*
Intercellular Adhesion Molecule-1 / blood
Middle Aged
Renin / blood
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins; 0/E-Selectin; 11128-99-7/Angiotensin II; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-41-4/C-Reactive Protein; EC

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