Document Detail

Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons co-infected with HIV and hepatitis viruses.
MedLine Citation:
PMID:  23335804     Owner:  NLM     Status:  Publisher    
Background. Hepatitis C (HCV) or B virus (HBV) co-infection with HIV increases mortality risk over either infection alone and is frequently associated with hepatitis flares upon antiretroviral therapy (ART) initiation.Methods. Retrospective cohort study of 287 HIV-positive persons co-infected with HBV or HCV (HBV n=70; HCV n=207; HBV+HCV n=10) who had pre-ART plasma samples evaluated for biomarkers associated with death (within 4 years) and/or hepatitis flare (within 4 months) after ART initiation. A predictive biomarker risk score was calculated.Results. 48 deaths and 50 hepatitis flares occurred. Non-survivors were older with more prior AIDS events and higher pre-ART triglycerides and AST levels. Detectable hyaluronic acid and higher D-dimer, IL-6, IL-8, and sCD14 levels were associated with death in univariate models and with a composite biomarker risk score. Risk of hepatitis flares was higher with HBV co-infection (24.3%) or both HBV and HCV (50%) displayed than with HCV co-infection only (13.5%). Higher levels of ALT and interleukin (IL)-10 were also associated with hepatitis flares.Conclusion. Among HIV patients co-infected with HBV and/or HCV initiating ART, biomarkers of inflammation and coagulation are associated with an increased risk of death while HBV co-infection and higher pre-ART IL-10 levels are associated with hepatitis flares.
Bruno Bezerril Andrade; Katherine Huppler Hullsiek; David R Boulware; Adam Rupert; Martyn A French; Kiat Ruxrungtham; Marisa Luisa Montes; Huw Price; Pablo Barreiro; Jennifer Audsley; Alan Sher; Sharon R Lewin; Irini Sereti;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-18
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  -     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, United States.
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