| Biomarkers in spondyloarthritis. | |
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MedLine Citation:
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PMID: 20714832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Key challenges in the management of spondyloarthritis focus on the lack of availability of measures of disease activity and the inability to predict joint damage or response to treatment, which is expensive and associated with potentially serious toxicity. Recent studies have focused on the possible contribution of soluble biomarkers, which have been selected based on current understanding of their role in inflammation and/or their association with turnover of joint matrix. Emerging candidates for disease activity markers include interleukin-6 and soluble cytotoxic T lymphocyte associated molecule-4. Potential predictors of damage include metalloproteinase-3 and sclerostin. Acute-phase reactants C-reactive protein and serum amyloid A and interleukin-6 are currently the best predictors of treatment response. Significant study limitations are small sample size and the lack of multivariate analyses that can determine whether the biomarker contributes information that is independent of other clinical and laboratory variables used in routine care. |
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Authors:
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Walter P Maksymowych |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current rheumatology reports Volume: 12 ISSN: 1534-6307 ISO Abbreviation: Curr Rheumatol Rep Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-12-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888970 Medline TA: Curr Rheumatol Rep Country: United States |
Other Details:
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Languages: eng Pagination: 318-24 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Alberta, 562 Heritage Medical Research Building, Edmonton, AB, T6G 2S2, Canada. walter.maksymowych@ualberta.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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metabolism,
urine Antigens, CD / blood, urine Biological Markers / blood*, urine* Bone Morphogenetic Proteins / blood, urine Disease Progression Genetic Markers Humans Inflammation / blood, physiopathology, urine Interleukin-6 / blood, urine Matrix Metalloproteinase 3 Spondylarthritis / blood*, physiopathology, therapy, urine* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Antigens, CD; 0/Biological Markers; 0/Bone Morphogenetic Proteins; 0/Genetic Markers; 0/Interleukin-6; 0/SOST protein, human; 0/cytotoxic T-lymphocyte antigen 4; EC 3.4.24.17/Matrix Metalloproteinase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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