Document Detail


Biomarkers in neonatal posthemorrhagic hydrocephalus.
MedLine Citation:
PMID:  21791933     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Posthemorrhagic hydrocephalus (PHH) is a rare but serious outcome among premature babies in the NICU, with consequences including mortality and severe neurodevelopmental disabilities. The causes of PHH are still not entirely understood, and its prevention and treatment are controversial. Various cerebrospinal fluid biomarkers have been studied in infants with PHH in order to recognize the causes, diagnose brain injury, and predict neurodevelopmental outcomes. This systematic review summarizes studies on biomarkers of extracellular matrix activity, fibrinolysis/coagulation, hypoxia/cell death, and inflammation in the cerebrospinal fluid of infants with PHH.
Authors:
Stephanie Merhar
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-07-27
Journal Detail:
Title:  Neonatology     Volume:  101     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2012  
Date Detail:
Created Date:  2011-12-22     Completed Date:  2012-07-19     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Affiliation:
Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA. stephanie.merhar@cchmc.org
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MeSH Terms
Descriptor/Qualifier:
Apoptosis
Biological Markers / cerebrospinal fluid*
Cerebral Hemorrhage / cerebrospinal fluid*
Cerebral Ventricles / pathology
Extracellular Matrix Proteins / metabolism
Fibrinolysis
Humans
Hydrocephalus / cerebrospinal fluid*
Infant, Newborn
Infant, Premature, Diseases / cerebrospinal fluid
Transforming Growth Factor beta1 / cerebrospinal fluid
Grant Support
ID/Acronym/Agency:
UL1 TR000077/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Extracellular Matrix Proteins; 0/Transforming Growth Factor beta1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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