Document Detail


[Biomarkers in community acquired pneumonia - what did we learn from the CAPNETZ study?].
MedLine Citation:
PMID:  21117019     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Biomarkers have been intensively studied in community-acquired pneumonia (CAP) in recent years. In the context of the CAPNETZ study we had the unique opportunity to evaluate old and new biomarkers in a multicentre study with a high number of patients.
RESULTS: In several substudies we found the following results: procalcitonin, CRP and leukocytes show highest values in patients with typical bacterial etiology of CAP, but do not allow individual prediction of etiology. Patients without antibiotic pre-treatment show higher values of biomarkers compared to patients with antibiotic pre-treatment. New cardiovascular biomarkers are good predictors for short- and long-term mortality in CAP, superior to the inflammatory markers procalcitonin, CRP and leukocytes and at least comparable to the clinical CRB-65 score. Pro-Adrenomedullin is among the new biomarkers the one with the best prognostic value.
CONCLUSIONS: Biomarkers correlate with the severity of CAP but do not allow individual prediction of etiology. New cardiovascular biomarkers are suitable for the evaluation of short- and long-term prognosis in CAP. The combination of several biomarkers reflecting different pathophysiological pathways has the potential to improve management of CAP in the future.
Authors:
S Krüger; M W Pletz; G Rohde
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Publication Detail:
Type:  English Abstract; Journal Article     Date:  2010-11-29
Journal Detail:
Title:  Pneumologie (Stuttgart, Germany)     Volume:  65     ISSN:  1438-8790     ISO Abbreviation:  Pneumologie     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906641     Medline TA:  Pneumologie     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  110-3     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Affiliation:
Medizinische Klinik I, Universitätsklinikum RWTH Aachen. stkrueger@ukaachen.de
Vernacular Title:
Biomarker bei ambulant erworbener Pneumonie - was haben wir aus CAPNETZ gelernt?
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