| Biomarkers of genotoxicity and genomic instability in a non-human primate, Cebus libidinosus (Cebidae, Platyrrhini), exposed to nitroimidazole derivatives. | |
| | |
MedLine Citation:
|
PMID: 21255674 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The genotoxicity of two nitroimidazole derivatives, ornidazole (ONZ) and metronidazole (MTZ) in the peripheral blood lymphocytes of Cebus libidinosus (CLI) (Primates, Cebidae) was assessed. Endpoints measured included sister chromatid exchange (SCE) frequency, cell proliferation kinetics (CPK), replication index (RI), mitotic index (MI), and damage incidence in or near CLI heterochromatin regions. MI and SCE values following ONZ or MTZ treatments were significantly different (p<0.001) from control. SCE frequency per chromosome was not proportional to chromosome length. The chromosomes most affected for SCE were 1, 2, 4, 6, 11-13, 17, and 18, many of which possess interstitial or terminal heterochromatin. In the CLI genome, chromosomes 11 and 17 showed higher susceptibility to damage RI was the only biomarker that did not show statistically significant differences between control and treated cultures. C. libidinosus bands 11q1.4 and 11q1.5 may be hot-spots in the context of nitroimidazole exposure. |
| | |
Authors:
|
Marta Dolores Mudry; Romari Alejandra Martinez; Mariela Nieves; Marta Ana Carballo |
Related Documents
:
|
21296154 - Identification and characterization of the fusion transcript, composed of the apterous ... 21403424 - Loss of philadelphia chromosome after graft failure following cord blood transplantatio... 21455484 - Interactions among polycomb domains are guided by chromosome architecture. 8710784 - Prenatal diagnosis of partial monosomy 3p and partial trisomy 2p in a fetus associated ... 18347314 - Paraoxonase 1 (pon1) organophosphate hydrolysis is not reduced in als. 1909864 - Why is mendelian segregation so exact? |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-19 |
Journal Detail:
|
Title: Mutation research Volume: - ISSN: 0027-5107 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
|
GIBE (Grupo de Investigación en Biología Evolutiva), Departamento de Ecología, Genética y Evolución (EGE), Facultad de Ciencias Exactas y Naturales (FCEyN), Universidad de Buenos Aires (UBA), (1428EHA) Buenos Aires, Argentina; CONICET, Argentina. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inflammation-induced airway smooth muscle responsiveness is strain dependent in mice.
Next Document: Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from...