Document Detail


Biomarkers and functional outcomes from ischaemic cerebral events in women: a prospective cohort study.
MedLine Citation:
PMID:  23034002     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Several biomarkers have been associated with an increased risk of ischaemic stroke. However, the association between these biomarkers and functional outcome from cerebral ischaemic events is unclear. We aimed to assess the patterns of association between cardiovascular disease biomarkers and functional outcomes after incident ischaemic cerebral events in women.
METHODS: Prospective cohort study of 27,728 women enrolled in the Women's Health Study who provided information on blood samples and were free of stroke or transient ischaemic attack (TIA) at baseline. Multinomial logistic regression was used to determine the association between elevated biomarker levels and functional outcomes from ischaemic cerebral events. Possible functional outcomes included TIA and ischaemic stroke with modified Rankin Scale (mRS) score of 0-1, 2-3, or 4-6.
RESULTS: After a mean follow-up of 15.1 years, 461 TIAs and 380 ischaemic strokes occurred. Elevated levels of total cholesterol were associated with the highest risk of poor functional outcome (mRS 4-6) after incident cerebral ischaemic events (relative risk = 2.02, 95% CI = 1.18-3.46). We observed significant associations between elevated levels of total cholesterol, Lp(a), C-reactive protein, and triglycerides, and mild or moderate functional outcomes after ischaemic cerebral events. Elevations in all other biomarkers were not significantly associated with functional outcomes.
CONCLUSIONS: Whilst total cholesterol level was associated with highest risks of poor functional outcome after stroke, we overall observed an inconsistent pattern of association between biomarkers linked with an increased risk of vascular events and more impaired functional outcomes from stroke.
Authors:
P M Rist; J E Buring; C S Kase; P M Ridker; T Kurth
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-03
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  20     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-07-18     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  375-81     Citation Subset:  IM    
Copyright Information:
© 2012 The Author(s) European Journal of Neurology © 2012 EFNS.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood*
C-Reactive Protein / analysis
Cholesterol / blood
Cohort Studies
Female
Humans
Inflammation Mediators / blood
Ischemic Attack, Transient / blood*
Middle Aged
Prospective Studies
Randomized Controlled Trials as Topic
Severity of Illness Index
Stroke / blood*
Treatment Outcome
Triglycerides / blood
Women's Health / statistics & numerical data*
Grant Support
ID/Acronym/Agency:
AG-00158/AG/NIA NIH HHS; CA-047988/CA/NCI NIH HHS; HL-043851/HL/NHLBI NIH HHS; HL-080467/HL/NHLBI NIH HHS; HL-099355/HL/NHLBI NIH HHS; R01 CA047988/CA/NCI NIH HHS; R01 HL043851/HL/NHLBI NIH HHS; R01 HL080467/HL/NHLBI NIH HHS; RC1 HL099355/HL/NHLBI NIH HHS; T32 AG000158/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators; 0/Triglycerides; 9007-41-4/C-Reactive Protein; 97C5T2UQ7J/Cholesterol
Comments/Corrections

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