| Biomarkers of extracellular matrix turnover. | |
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MedLine Citation:
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PMID: 19631182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The extracellular cardiac matrix (ECCM) plays an important role in the support of myocytes and fibroblasts. ECCM turnover is influenced by ischemia, stretch, inflammation, and neurohormonal mediators. Myocardial fibrosis is the consequence of several pathologic processes mediated by mechanical, neurohormonal, and cytokine factors. It is a major determinant of diastolic dysfunction and pumping capacity and may result in tissue heterogeneity, dys-synchrony, and arrhythmias. The measurement of various serum peptides arising from the metabolism of collagen types 1 and 3, of degradation fragments, and of specific metalloproteinases may provide noninvasive assessment of fibrosis. ECCM biomarkers are clinically useful tools, particularly given the potential for cardioprotective and cardioreparative pharmacologic strategies. |
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Authors:
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Faiez Zannad; Bertram Pitt |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Heart failure clinics Volume: 5 ISSN: 1551-7136 ISO Abbreviation: - Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-07-27 Completed Date: 2009-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101231934 Medline TA: Heart Fail Clin Country: United States |
Other Details:
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Languages: eng Pagination: 589-99 Citation Subset: IM |
Affiliation:
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Hôpital Jeanne d'Arc, Dommartin-les-Toul, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone Antagonists
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therapeutic use Biological Markers / blood Extracellular Matrix / drug effects, pathology* Heart Failure / blood*, diagnosis*, etiology Humans Myocardial Infarction / etiology Myocardial Ischemia / etiology |
| Chemical | |
Reg. No./Substance:
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0/Aldosterone Antagonists; 0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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