Document Detail


Biomarkers of exposure to cyanogens in horses with grass sickness.
MedLine Citation:
PMID:  12408327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To test the hypothesis that equine grass sickness may be associated with the ingestion of cyanogenic glycosides from white clover (Trifolium repens), the concentrations of whole blood cyanide, and plasma and urinary thiocyanate, the main metabolite of cyanide, were measured in 12 horses with acute grass sickness and 10 horses with subacute grass sickness, and in 43 control horses, of which 21 were co-grazing with cases of acute grass sickness, 12 grazed pastures where grass sickness had not been reported, and 10 were stabled horses. The healthy horses which grazed with cases of acute grass sickness had higher concentrations of blood cyanide, and plasma and urinary thiocyanate than the other control horses, consistent with an increased exposure to cyanogens. The horses with grass sickness had no evidence of a recent intake of cyanogens, but may have been exposed to increased levels of cyanogens before they became anorexic.
Authors:
B C McGorum; R A Anderson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Veterinary record     Volume:  151     ISSN:  0042-4900     ISO Abbreviation:  Vet. Rec.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-31     Completed Date:  2003-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0031164     Medline TA:  Vet Rec     Country:  England    
Other Details:
Languages:  eng     Pagination:  442-5     Citation Subset:  IM    
Affiliation:
Department of Veterinary Clinical Studies, Easter Bush Veterinary Centre, Roslin, Midlothian.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers
Chromatography, Gas
Cyanides / blood*
Female
Glycosides / metabolism,  poisoning*
Horse Diseases / blood*
Horses
Male
Thiocyanates / urine*
Trifolium / poisoning*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cyanides; 0/Glycosides; 0/Thiocyanates; 0/cyanogenic glycosides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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