Document Detail

Biomarkers of exercise-induced myocardial stress in relation to inflammatory and oxidative stress.
MedLine Citation:
PMID:  18198658     Owner:  NLM     Status:  MEDLINE    
Increased concentrations of biomarkers reflecting myocardial stress such as cardiac troponin I and T and brain natriuretic peptide (BNP) have been observed following strenuous, long-lasting endurance exercise. The pathophysiological mechanisms are still not fully elucidated and the interpretations of increased post-exercise concentrations range from (i) evidence for exercise-induced myocardial damage to (ii) non-relevant spurious troponin elevations, presumably caused by assay imprecision or heterophilic antibodies. Several lines of evidence suggest that inflammatory processes or oxidative stress could be involved in the rise of NT-proBNP and Troponin observed in critically ill patients with sepsis or burn injury. We tested the hypothesis that inflammatory or oxidative stress is also responsible for exercise-induced cardiomyocyte strain in a large cohort of triathletes following an Ironman triathlon. However, the post-race increase in cardiac troponin T and NT-proBNP was not associated with several markers of exercise-induced inflammation, oxidative stress or antioxidant vitamins. Therefore, we clearly need more studies with other inflammatory markers and different designs to elucidate the scientific background for increases in myocardial stress markers following strenuous endurance events.
Daniel König; Oliver Neubauer; Lukas Nics; Norbert Kern; Aloys Berg; Emmanuel Bisse; Karl-Heinz Wagner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Exercise immunology review     Volume:  13     ISSN:  1077-5552     ISO Abbreviation:  Exerc Immunol Rev     Publication Date:  2007  
Date Detail:
Created Date:  2008-01-17     Completed Date:  2008-02-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505535     Medline TA:  Exerc Immunol Rev     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  15-36     Citation Subset:  IM    
Centre for Internal Medicine, Division of Rehabilitation, Prevention and Sports Medicine, Freiburg University Hospital, Hugstetterstr. 55, 79106 Freiburg, Germany.
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MeSH Terms
Biological Markers / blood
Exercise / physiology*
Inflammation / metabolism*
Myocardium / immunology,  metabolism*
Natriuretic Peptide, Brain / blood*
Oxidative Stress / immunology*
Peptide Fragments / blood*
Predictive Value of Tests
Troponin / blood*
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/Troponin; 0/pro-brain natriuretic peptide (1-76); 114471-18-0/Natriuretic Peptide, Brain

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