| Biomarkers of esophageal adenocarcinoma and Barrett's esophagus. | |
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MedLine Citation:
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PMID: 14996709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rising incidence and poor prognosis of esophageal adenocarcinoma in the Western world have intensified research efforts into earlier methods of detection of this disease and its relationship to Barrett's esophagus. The progression of Barrett's esophagus to adenocarcinoma has been the focus of particular scrutiny, and a number of potential tissue and serum-based disease biomarkers have emerged. The epidemiology and pathogenesis of esophageal adenocarcinoma are outlined. Tissue biomarkers allowing risk stratification of Barrett's are reviewed as well as strategies currently being used to discover novel biomarkers that will facilitate the early detection of esophageal adenocarcinoma. Finally, the uses of biomarkers as predictive tests for targeted treatments and as surrogate endpoints in chemoprevention trials are considered. |
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Authors:
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Damian T McManus; Andreea Olaru; Stephen J Meltzer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cancer research Volume: 64 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-03-03 Completed Date: 2004-03-31 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 1561-9 Citation Subset: IM |
Affiliation:
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Histopathology/Cytopathologist, Belfast City Hospital Trust, Belfast, Northern Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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diagnosis,
epidemiology,
etiology* Barrett Esophagus / complications*, diagnosis Biological Markers Cyclin D1 / analysis DNA, Neoplasm / analysis Esophageal Neoplasms / diagnosis, epidemiology, etiology* Humans Tumor Markers, Biological Tumor Suppressor Protein p53 / analysis |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/DNA, Neoplasm; 0/Tumor Markers, Biological; 0/Tumor Suppressor Protein p53; 136601-57-5/Cyclin D1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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