Document Detail

Biomarkers of endothelial dysfunction are elevated and related to prognosis in chronic heart failure patients with diabetes but not in those without diabetes.
MedLine Citation:
PMID:  18343722     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Biomarkers of endothelial dysfunction, such as soluble E-selectin, and von Willebrand factor (vWf) are elevated in patients with chronic heart failure (CHF). The impact of diabetes mellitus (DM) on these biomarkers, and their relation to prognosis remains unknown.
AIMS: to investigate the impact of DM on plasma levels and the prognostic value of E-selectin and vWf in patients with CHF.
METHODS AND RESULTS: Plasma levels of E-selectin and vWf were measured in 195 CHF patients with (n=48, 24.5%), and without DM, and in 116 age-matched healthy controls. Compared with controls, median plasma E-selectin levels were higher in CHF patients with DM (P=0.012), but not in CHF patients without DM (P=0.45); vWf levels were also higher in CHF patients with DM (P<0.001), but not without DM (P=0.108). E-selectin was associated with risk of recurrent ischaemic cardiovascular events among CHF patients with DM (HR 2.60; P=0.009), but not among patients without DM (HR 1.09; P=0.60) per 1 SD increment in log transformed variable. vWf was not related with outcome in CHF patients with or without DM.
CONCLUSIONS: Plasma levels of E-selectin and vWf are elevated in CHF patients with DM but not in those without DM. High E-selectin levels may be associated with ischaemic events in patients with DM.
Caroline Kistorp; Aun Y Chong; Finn Gustafsson; Søren Galatius; Ilan Raymond; Jens Faber; Gregory Y H Lip; Per Hildebrandt
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-17
Journal Detail:
Title:  European journal of heart failure     Volume:  10     ISSN:  1388-9842     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-08     Completed Date:  2008-09-22     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  380-7     Citation Subset:  IM    
Department of Endocrinology, Herlev University Hospital, Copenhagen, Denmark.
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MeSH Terms
Biological Markers / blood
Diabetes Mellitus / blood*
E-Selectin / blood*
Endothelium, Vascular / physiopathology*
Heart Failure / blood*,  diagnosis,  mortality
Middle Aged
Myocardial Ischemia / blood,  diagnosis,  mortality
Proportional Hazards Models
Risk Factors
Survival Analysis
von Willebrand Factor / metabolism*
Reg. No./Substance:
0/Biological Markers; 0/E-Selectin; 0/von Willebrand Factor

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