Document Detail

Biomarkers for the diagnosis of deep vein thrombosis.
MedLine Citation:
PMID:  23480737     Owner:  NLM     Status:  In-Data-Review    
Venous thromboembolic disease (VTE) remains a significant source of morbidity and mortality. As non-specific subjective complaints and a paucity of objective clinical examination findings complicate the diagnosis of both deep venous thrombosis (DVT) and pulmonary embolism, diagnostic modalities remain essential. Compression ultrasound remains the gold standard for DVT diagnosis. Reliable imaging is not always available making a serologic diagnosis, or biomarker, highly desirable. While D-dimer, a highly sensitive biomarker, is useful for excluding acute VTE, it lacks the specificity necessary for diagnostic confirmation. As such, ongoing research efforts target and support the utility of alternative plasma biomarkers to aid in the diagnosis of VTE including selectins, microparticles, IL-10 and other inflammatory markers. These molecular markers may also predict recurrence risk, guide length and modality of treatment, and predict which thrombi will resolve spontaneously or recanalize, thus potentially identifying patients who would benefit from more aggressive therapies than standard anticoagulation.
Dawn M Coleman; Thomas W Wakefield
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Publication Detail:
Type:  Journal Article     Date:  2012-06-06
Journal Detail:
Title:  Expert opinion on medical diagnostics     Volume:  6     ISSN:  1753-0067     ISO Abbreviation:  Expert Opin Med Diagn     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2013-03-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392201     Medline TA:  Expert Opin Med Diagn     Country:  England    
Other Details:
Languages:  eng     Pagination:  253-7     Citation Subset:  IM    
University of Michigan Cardiovascular Center, Department of Surgery, From the Section of Vascular Surgery , 1500 East Medical Center Drive, Ann Arbor, MI 48109-5867 , USA +1 734 232 3968 ; +1 734 647 9867 ;
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