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Biomarkers of calcification and atherosclerosis in patients with degenerative aortic stenosis in relation to concomitant coronary artery disease.
MedLine Citation:
PMID:  22237719     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Discussion on aortic valve degenerative processes is still lasting. Markers of calcification and atherosclerosis may allow the background of these processes to be distinguished. OBJECTIVES: to assess the biochemical markers of the calcification and atherosclerotis in patients with degenerative aortic stenosis (AS) in relation to the aortic valve calcium score (AVCS) and concomitant coronary artery disease (CAD). PATIENTS AND METHODS: Eighty eighth patients (pts) were enrolled into the study: 68 pts with degenerative AS (group A) including 44 pts with severe AS (subgroup A1 - 25 pts with CAD) and 24 pts with moderate AS (subgroup A2 - 13 pts with CAD) and 20 matched subjects as controls (group C - 18 pts with CAD). Clinical data, laboratory tests - including interleukin-4 (IL-4), osteoprotegerin (OPG), and fetuin-A serum levels analysis, coronary angiography and AVCS were assessed in all subjects. RESULTS: Groups and subgroups examined revealed comparable IL-4, OPG and fetuin-A serum concentrations. There were significant differences in AVCS - severe AS: 3605 ± 2542; moderate AS: 1390 ± 1143; controls: 100 ± 194 Ag.units (AU) (p<0.001). There were no significant relations between AVCS and IL-4, OPG or fetuin-A serum levels. In moderate AS the serum OPG concentration was higher in subjects with concomitant CAD: 5.84 ± 1.4 vs 4.03 ± 1.3 pmol/l (p=0.036). Mean AVCS values did not differ between patients with and without CAD in all group and in patients with severe AS. Higher AVCS values were only observed in patients with moderate AS when AS coexisted with CAD (1644 ± 1285 AU vs 902 ± 789 AU, p=0.038). CONCLUSIONS: Serum levels of biochemical markers do not differentiate patients with and without degenerative AS. The prevalence of CAD in moderate AS is associated with increased AVCS and OPG serum level suggesting a promoting role of atherosclerosis in early valve calcification. In severe AS no relations between the calcification and atherosclerotic markers are found.
Tomasz Adamczyk; Katarzyna Mizia-Stec; Magdalena Mizia; Maciej Haberk; Artur Chmiel; Jerzy Chudek; Zbigniew Gąsior
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-11
Journal Detail:
Title:  Polskie Archiwum Medycyny Wewnetrznej     Volume:  -     ISSN:  1897-9483     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401225     Medline TA:  Pol Arch Med Wewn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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