Document Detail

Biomarkers of brain damage in preterm infants.
MedLine Citation:
PMID:  22958034     Owner:  NLM     Status:  In-Data-Review    
Objective: There is growing evidence on the usefulness of biomarkers in the early detection of preterm infants at risk for brain damage. However, among different tools Activin A, S100B protein and adrenomedullin assessment offer the possibility to investigate brain/multiorgan function and development. This could be especially useful in perinatal medicine that requires even more non-invasive techniques in order to fulfill the minimal handling in diagnostic and therapeutic strategy performance. Materials and methods: The concept of Unconventional Biological Fluid (UBF: urine and saliva) is becoming even stronger and regards the assessment in non-invasive biological fluids of biochemical markers involved in the cascade of events leading to brain damage. Results: Activin A, S100B protein and adrenomedullin in UBF were increased in preterm newborns developing brain damage and/or ominous outcome. Conclusions: The present manuscript offers an update on the usefulness of Activin A, S100B protein an adrenomedullin in UBF as brain damage markers. The findings open a new cue on the use of these markers in daily neonatal intensive care unit (NICU) activities.
Francesco M Risso; Andrea Sannia; Danilo A W Gavilanes; Hans J Vles; Micaela Colivicchi; Alberto Ricotti; Giovanni Li Volti; Diego Gazzolo
Related Documents :
7489074 - Longitudinal head growth in developmentally normal preterm infants.
17573964 - Longevity and growth of acacia tortilis; insights from 14c content and anatomy of wood.
21057284 - The 2009 pempix photo competition award winner: david kessler, md, msc: hey doc, what's...
15691774 - Prenatal diagnosis of fetal growth restriction.
9522844 - Infant mortality in a deprived area of papua new guinea: priorities for antenatal servi...
24766264 - Nonreassuring fetal heart rate decreases heart rate variability in newborn infants.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  25 Suppl 4     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  93-6     Citation Subset:  IM    
Department of Neonatology, G Gaslini Children's University Hospital , Genoa , Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cerebral and somatic rSO(2) in sick preterm infants.
Next Document:  Neuroprotective role of erythropoietin in neonates.