Document Detail

Biomarkers of vascular dysfunction in children infected with human immunodeficiency virus-1.
MedLine Citation:
PMID:  20531209     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: : We compared biomarkers of vascular dysfunction among HIV-infected children to a demographically similar group of uninfected children and determined factors associated with these biomarkers.
METHODS AND RESULTS: : We measured several biomarkers of vascular dysfunction: C-reactive protein (CRP), interleukin-6 (IL-6), and monocyte chemoattractant protein -1 (MCP-1) (inflammation); fibrinogen and P-selectin (coagulant dysfunction); soluble intracellular cell adhesion molecule-1 (sICAM), soluble vascular cell adhesion molecule-1 (sVCAM), and E-selectin (endothelial dysfunction); and leptin (metabolic dysfunction). Anthropometry, body composition, CD4%, HIV viral load, and antiretroviral therapy were recorded. Mean age was 14.8 years (106 HIV-infected children) and 12.3 years (55 control children). Sex and body mass index Z scores were similar. Infected children had higher sICAM, sVCAM, MCP-1, IL-6, and fibrinogen levels. E-selectin (P = 0.07), and CRP (P = 0.08) trended to be greater in the HIV group, yet leptin and P-selectin were similar. In multivariable analyses in the HIV-infected children alone, each 1 standard deviation increase in waist to hip ratio was associated with increases in sICAM (17%), MCP-1 (19%), IL6 (18%), and CRP (59%). CD4% was inversely associated with sVCAM, MCP-1, IL6, fibrinogen, and CRP.
CONCLUSIONS: : HIV-infected children have higher levels of biomarkers of vascular dysfunction than healthy children. Risk factors associated with these biomarkers include higher waist to hip ratios and HIV disease severity.
Tracie L Miller; Gabriel Somarriba; E John Orav; Armando J Mendez; Daniela Neri; Natasha Schaefer; Lourdes Forster; Ronald Goldberg; Gwendolyn B Scott; Steven E Lipshultz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  55     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2010-10-08     Revised Date:  2014-05-12    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  182-8     Citation Subset:  IM; X    
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MeSH Terms
Biological Markers / blood*
Blood Vessels / physiopathology*
C-Reactive Protein / analysis
Case-Control Studies
Chemokine CCL2 / blood
E-Selectin / blood
Fibrinogen / analysis
HIV Infections / blood*,  physiopathology
Leptin / blood
Multivariate Analysis
P-Selectin / blood
Vascular Cell Adhesion Molecule-1 / blood
Waist-Hip Ratio
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/CCL2 protein, human; 0/Chemokine CCL2; 0/E-Selectin; 0/Leptin; 0/P-Selectin; 0/Vascular Cell Adhesion Molecule-1; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein
Comment In:
Biomark Med. 2010 Oct;4(5):751   [PMID:  20945989 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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