| Biomarkers of Therapeutic Response to BCL2 Antagonists in Cancer. | |
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MedLine Citation:
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PMID: 23023732 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Cancer cells persist by resisting programmed cell death or apoptosis. In particular, an imbalance of proteins that regulate apoptosis leads to lack of response to apoptotic stimuli. Thus, restoring the ability of cancer cells to undergo apoptosis is highly desirable. One apoptosis pathway, the intrinsic pathway, involves perturbation of the mitochondria. The major players of this pathway are the members of the B cell CLL/lymphoma 2 (BCL2) family. Currently, three BCL2 antagonists are in clinical trials for cancer treatment. While these antagonists show various specificity and potency, the development of companion diagnostics is crucial for developing these compounds into viable cancer treatments. In this review we describe predictive and pharmacodynamic biomarkers for these agents. Future directions on biomarker development for this class of antagonist are also discussed. |
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Authors:
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Lloyd T Lam; Haichao Zhang; Brenda Chyla |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-29 |
Journal Detail:
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Title: Molecular diagnosis & therapy Volume: - ISSN: 1177-1062 ISO Abbreviation: Mol Diagn Ther Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-10-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264260 Medline TA: Mol Diagn Ther Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department R4CD, Global Pharmaceutical R&D, Abbott Laboratories, Building AP-10, 100 Abbott Park Road, Abbott Park, IL, 60064, USA, lloyd.lam@abbott.com. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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