Document Detail

Biomarkers of PTSD: neuropeptides and immune signaling.
MedLine Citation:
PMID:  21392516     Owner:  NLM     Status:  MEDLINE    
The biological underpinnings for participation of the immune system in the pathogenesis of Posttraumatic Stress Disorder (PTSD) include evidence for cross-talk between the stress and immune systems, as well as more recently discovered roles for immune system mediators in core behavioral functions such as adult neurogenesis, as well as in processes that underlay synaptic plasticity, such as learning and memory. This article reviews the expanding body of literature on immune system mediators in the periphery and the central nervous system (CNS) in chronic PTSD along with the evidence for increased peripheral inflammation, and excess morbidity and mortality. CNS inflammation has been implicated in the pathogenesis of depression. This literature is briefly reviewed, along with evidence for a possible role for CNS inflammation in PTSD symptoms, especially in individuals who have PTSD with co-morbid depression. Whether the immune system is involved in risk and resilience, or evolution of PTSD symptoms following a trauma event remains to be determined, although hypotheses have been advanced. This paper reviews the current evidence including the novel hypothesis that cellular immunity is implicated in PTSD risk and resilience. Potential research implications and directions are discussed. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.
Dewleen G Baker; Caroline M Nievergelt; Daniel T O'Connor
Related Documents :
7490476 - Interferon-gamma-dependent stimulation of fas antigen in sv40-transformed human keratin...
16778096 - Fas signaling in thyroid carcinomas is diverted from apoptosis to proliferation.
9045916 - Reduced susceptibility to fas-mediated apoptosis in b-1 cells.
8691726 - Anti-fas antibodies induce cytolysis and apoptosis in cultured human mesangial cells.
22368256 - The role of p53 in an apoptotic process caused by an oral malodorous compound in period...
15238076 - Antigen-specific in vitro suppression of murine helicobacter pylori-reactive immunopath...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2011-03-22
Journal Detail:
Title:  Neuropharmacology     Volume:  62     ISSN:  1873-7064     ISO Abbreviation:  Neuropharmacology     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-20     Completed Date:  2012-07-27     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  663-73     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Biological Markers / blood
Immune System / immunology*
Inflammation / blood,  immunology
Neuropeptides / blood*
Stress Disorders, Post-Traumatic / blood,  immunology*
Grant Support
1 R01 AG030474-01A2/AG/NIA NIH HHS; 1 U01 MH092758-01/MH/NIMH NIH HHS; HL58120/HL/NHLBI NIH HHS; MD000220/MD/NIMHD NIH HHS; R01 MH093500/MH/NIMH NIH HHS; R01 MH093500-01/MH/NIMH NIH HHS; RR031980/RR/NCRR NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Neuropeptides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  5-HT(4) Receptor Agonist Mediated Enhancement of Cognitive Function In Vivo and Amyloid Precursor Pr...
Next Document:  A pattern of perseveration in cocaine addiction may reveal neurocognitive processes implicit in the ...