Document Detail


Biomarkers of PTSD: neuropeptides and immune signaling.
MedLine Citation:
PMID:  21392516     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biological underpinnings for participation of the immune system in the pathogenesis of Posttraumatic Stress Disorder (PTSD) include evidence for cross-talk between the stress and immune systems, as well as more recently discovered roles for immune system mediators in core behavioral functions such as adult neurogenesis, as well as in processes that underlay synaptic plasticity, such as learning and memory. This article reviews the expanding body of literature on immune system mediators in the periphery and the central nervous system (CNS) in chronic PTSD along with the evidence for increased peripheral inflammation, and excess morbidity and mortality. CNS inflammation has been implicated in the pathogenesis of depression. This literature is briefly reviewed, along with evidence for a possible role for CNS inflammation in PTSD symptoms, especially in individuals who have PTSD with co-morbid depression. Whether the immune system is involved in risk and resilience, or evolution of PTSD symptoms following a trauma event remains to be determined, although hypotheses have been advanced. This paper reviews the current evidence including the novel hypothesis that cellular immunity is implicated in PTSD risk and resilience. Potential research implications and directions are discussed. This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'.
Authors:
Dewleen G Baker; Caroline M Nievergelt; Daniel T O'Connor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2011-03-22
Journal Detail:
Title:  Neuropharmacology     Volume:  62     ISSN:  1873-7064     ISO Abbreviation:  Neuropharmacology     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-20     Completed Date:  2012-07-27     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  0236217     Medline TA:  Neuropharmacology     Country:  England    
Other Details:
Languages:  eng     Pagination:  663-73     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood
Humans
Immune System / immunology*
Inflammation / blood,  immunology
Neuropeptides / blood*
Stress Disorders, Post-Traumatic / blood,  immunology*
Grant Support
ID/Acronym/Agency:
1 R01 AG030474-01A2/AG/NIA NIH HHS; 1 U01 MH092758-01/MH/NIMH NIH HHS; HL58120/HL/NHLBI NIH HHS; MD000220/MD/NIMHD NIH HHS; R01 MH093500/MH/NIMH NIH HHS; R01 MH093500-01/MH/NIMH NIH HHS; RR031980/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Neuropeptides

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