| Biomarkers of manganese intoxication. | |
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MedLine Citation:
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PMID: 20946915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Manganese (Mn), upon absorption, is primarily sequestered in tissue and intracellular compartments. For this reason, blood Mn concentration does not always accurately reflect Mn concentration in the targeted tissue, particularly in the brain. The discrepancy between Mn concentrations in tissue or intracellular components means that blood Mn is a poor biomarker of Mn exposure or toxicity under many conditions and that other biomarkers must be established. For group comparisons of active workers, blood Mn has some utility for distinguishing exposed from unexposed subjects, although the large variability in mean values renders it insensitive for discriminating one individual from the rest of the study population. Mn exposure is known to alter iron (Fe) homeostasis. The Mn/Fe ratio (MIR) in plasma or erythrocytes reflects not only steady-state concentrations of Mn or Fe in tested individuals, but also a biological response (altered Fe homeostasis) to Mn exposure. Recent human studies support the potential value for using MIR to distinguish individuals with Mn exposure. Additionally, magnetic resonance imaging (MRI), in combination with noninvasive assessment of γ-aminobutyric acid (GABA) by magnetic resonance spectroscopy (MRS), provides convincing evidence of Mn exposure, even without clinical symptoms of Mn intoxication. For subjects with long-term, low-dose Mn exposure or for those exposed in the past but not the present, neither blood Mn nor MRI provides a confident distinction for Mn exposure or intoxication. While plasma or erythrocyte MIR is more likely a sensitive measure, the cut-off values for MIR among the general population need to be further tested and established. Considering the large accumulation of Mn in bone, developing an X-ray fluorescence spectroscopy or neutron-based spectroscopy method may create yet another novel non-invasive tool for assessing Mn exposure and toxicity. |
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Authors:
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Wei Zheng; Sherleen X Fu; Ulrike Dydak; Dallas M Cowan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review Date: 2010-10-12 |
Journal Detail:
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Title: Neurotoxicology Volume: 32 ISSN: 1872-9711 ISO Abbreviation: Neurotoxicology Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-28 Completed Date: 2011-12-09 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA. wzheng@purdue.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / metabolism Body Fluids / drug effects, metabolism Brain / drug effects, metabolism*, pathology Humans Magnetic Resonance Imaging / methods Magnetic Resonance Spectroscopy / methods Manganese / metabolism*, toxicity* Oxidative Stress / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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OH 008615/OH/NIOSH CDC HHS; R01 ES008146-14/ES/NIEHS NIH HHS; R01-ES008146/ES/NIEHS NIH HHS; R21 ES017055-02/ES/NIEHS NIH HHS; R21-ES017055/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 7439-96-5/Manganese |
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