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Biomarker-guided therapies in heart failure: a forum for unified strategies.
MedLine Citation:
PMID:  23910590     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The complexity of standard medical treatment for heart failure is growing, and such therapy typically involves 5 or more different medications. Given these pressures, there is increasing interest in harnessing cardiovascular biomarkers for clinical application to more effectively guide diagnosis, risk stratification, and therapy. It may be possible to realize an era of personalized medicine for heart failure treatment in which therapy is optimized and costs are controlled. The direct mechanistic coupling of biologic processes and therapies achieved in cancer treatment remains elusive in heart failure. Recent clinical trials and meta-analyses of biomarkers in heart failure have produced conflicting evidence. In this article, which comprises a summary of discussions from the Global Cardiovascular Clinical Trialists Forum held in Paris, France, we offer a brief overview of the background and rationale for biomarker testing in heart failure, describe opportunities and challenges from a regulatory perspective, and summarize current positions from government agencies in the United States and European Union.
Authors:
Mona Fiuzat; Christopher M O'Connor; Francois Gueyffier; Alice M Mascette; Nancy L Geller; Alexandre Mebazaa; Adriaan A Voors; Kirkwood F Adams; Ileana L Piña; Ludwig Neyses; Pieter Muntendam; G Michael Felker; Bertram Pitt; Faiez Zannad; Michael R Bristow
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  19     ISSN:  1532-8414     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  592-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Affiliation:
Duke University Medical Center, Durham, North Carolina. Electronic address: mona.fiuzat@duke.edu.
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