Document Detail

Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview.
MedLine Citation:
PMID:  20804336     Owner:  NLM     Status:  MEDLINE    
Pregnancy-associated plasma protein-A (PAPP-A) is highly efficient as a serum marker in first-trimester screening for chromosomal abnormalities. Furthermore, there is increasing evidence that low levels of PAPP-A in the first trimester are associated with adverse pregnancy outcomes such as preterm delivery, intrauterine growth retardation, preeclampsia, and stillbirth. PAPP-A is a glycoprotein, produced in the placenta, and it is present in the maternal circulation in increasing concentrations during pregnancy. By means of its proteolytic activity, PAPP-A functions as a regulatory protein in the insulin-like growth factor system, known to be important for placental formation and regulation of fetal growth. This overview describes aspects of biochemistry, synthesis, and biological functions of PAPP-A, with a focus on information of importance to clinicians. The clinical applications of PAPP-A are summarized, and new insights regarding the analyses of PAPP-A discussed.
Ida Kirkegaard; Niels Uldbjerg; Claus Oxvig
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  89     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  1118-25     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Aarhus, Denmark.
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MeSH Terms
Biological Markers / blood
Cardiovascular Diseases / blood,  diagnosis
Chromosome Aberrations
Eosinophil Major Basic Protein / blood
Pregnancy Complications / diagnosis
Pregnancy Trimester, First
Pregnancy-Associated Plasma Protein-A / analysis*
Prenatal Diagnosis*
Somatomedins / physiology
Reg. No./Substance:
0/Biological Markers; 0/Somatomedins; EC 3.1.27.-/Eosinophil Major Basic Protein; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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