| Biology of pregnancy-associated plasma protein-A in relation to prenatal diagnostics: an overview. | |
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MedLine Citation:
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PMID: 20804336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pregnancy-associated plasma protein-A (PAPP-A) is highly efficient as a serum marker in first-trimester screening for chromosomal abnormalities. Furthermore, there is increasing evidence that low levels of PAPP-A in the first trimester are associated with adverse pregnancy outcomes such as preterm delivery, intrauterine growth retardation, preeclampsia, and stillbirth. PAPP-A is a glycoprotein, produced in the placenta, and it is present in the maternal circulation in increasing concentrations during pregnancy. By means of its proteolytic activity, PAPP-A functions as a regulatory protein in the insulin-like growth factor system, known to be important for placental formation and regulation of fetal growth. This overview describes aspects of biochemistry, synthesis, and biological functions of PAPP-A, with a focus on information of importance to clinicians. The clinical applications of PAPP-A are summarized, and new insights regarding the analyses of PAPP-A discussed. |
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Authors:
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Ida Kirkegaard; Niels Uldbjerg; Claus Oxvig |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 89 ISSN: 1600-0412 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-31 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: England |
Other Details:
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Languages: eng Pagination: 1118-25 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Aarhus University Hospital, Skejby, Aarhus, Denmark. ida.kirkegaard@ki.au.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Cardiovascular Diseases / blood, diagnosis Chromosome Aberrations Eosinophil Major Basic Protein / blood Female Humans Pregnancy Pregnancy Complications / diagnosis Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A / analysis* Prenatal Diagnosis* Somatomedins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Somatomedins; EC 3.1.27.-/Eosinophil Major Basic Protein; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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