Document Detail

Biology of neuroblastomas that were found by mass screening at 6 months of age in Japan.
MedLine Citation:
PMID:  16078225     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Mass screening (MS) of neuroblastoma has been carried out by measuring the urinary catecholamine metabolites in infants at the age of 6 months in Japan. We assessed the incidence of neuroblastoma that may be a target for MS by studying tumor biology. PROCEDURE: FISH on chromosome 1 and MYCN analysis was performed on 453 patients that were classified into three clinical groups (287 infants found by MS, 51 infants < 12 months diagnosed clinically, and 115 children >or=12 months diagnosed clinically). The relationship between the biological types of tumors and the clinical outcome was examined. RESULTS: Type 1 (trisomy 1 and normal MYCN), type 2 (disomy 1/tetrasomy 1 and normal MYCN), and type 3 (disomy 1/tetrasomy 1 and amplified MYCN) tumors were found in 88.2%, 10.5%, and 1.4% of infants found by MS, in 68.0%, 24.0%, and 8.0% of infants diagnosed clinically, and in 23.4%, 42.3%, and 34.2% of children diagnosed clinically (P < 0.001). Infants with type 1 tumors found by MS or diagnosed clinically had earlier stages of the disease (P < 0.0001 and P = 0.0005) and better overall survival (P < 0.001 and P = 0.005) than children with type 1 tumors diagnosed clinically. Infants with type 2 tumors found by MS, had earlier stages (P = 0.06 and P < 0.0001) and better overall survival (P = 0.014 and P < 0.001) than infants or children with type 2 tumors diagnosed clinically. All three clinical groups of patients with type 3 tumors had advanced stages and dismal prognoses. CONCLUSIONS: About 12% of tumors found by MS showed unfavorable biological (types 2 and 3) characteristics.
Yasuhiko Kaneko; Hirofumi Kobayashi; Naoki Watanabe; Nobumoto Tomioka; Akira Nakagawara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  46     ISSN:  1545-5009     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-04-13     Revised Date:  2009-01-12    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  285-91     Citation Subset:  IM    
Division of Cancer Diagnosis, Research Institute for Clinical Oncology and Department of Hematology, Saitama Cancer Center, Saitama, Japan.
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MeSH Terms
Child, Preschool
Chromosomes, Human, Pair 1 / genetics*
Disease-Free Survival
In Situ Hybridization, Fluorescence / methods
Infant, Newborn
Mass Screening / methods
Neuroblastoma / classification,  diagnosis,  genetics*,  mortality
Nuclear Proteins / genetics*
Oncogene Proteins / genetics*
Predictive Value of Tests
Retrospective Studies
Reg. No./Substance:
0/MYCN protein, human; 0/Nuclear Proteins; 0/Oncogene Proteins
Comment In:
Pediatr Blood Cancer. 2006 Mar;46(3):271-2   [PMID:  16078229 ]

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