Document Detail

Biology of hypoxia-inducible factor-2alpha in development and disease.
MedLine Citation:
PMID:  18259197     Owner:  NLM     Status:  MEDLINE    
The transcriptional response to hypoxia is primarily mediated by two hypoxia-inducible factors--HIF-1alpha and HIF-2alpha. While these proteins are highly homologous, increasing evidence suggests they have unique transcriptional targets and differential impact on tumor growth. Furthermore, non-transcriptional effects of the HIF-alpha subunits, including effects on the Notch and c-Myc pathways, contribute to their distinct functions. HIF-2alpha transcriptional targets include genes involved in erythropoiesis, angiogenesis, metastasis, and proliferation. Therefore, HIF-2alpha contributes significantly to both normal physiology as well as tumorigenesis. Here, we summarize the function of HIF-2alpha during development as well as its contribution to pathologic conditions, such as tumors and vascular disease.
S A Patel; M C Simon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-02-15
Journal Detail:
Title:  Cell death and differentiation     Volume:  15     ISSN:  1350-9047     ISO Abbreviation:  Cell Death Differ.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-06-13     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  9437445     Medline TA:  Cell Death Differ     Country:  England    
Other Details:
Languages:  eng     Pagination:  628-34     Citation Subset:  IM    
Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
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MeSH Terms
Anoxia / genetics,  metabolism*
Basic Helix-Loop-Helix Transcription Factors / genetics,  metabolism*
Cell Hypoxia
Cell Transformation, Neoplastic / metabolism
Gene Expression Regulation, Neoplastic
Mice, Knockout
Neoplasms / genetics,  metabolism*
Signal Transduction*
Tissue Distribution
Transcription, Genetic
Grant Support
//Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/endothelial PAS domain-containing protein 1

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