| Biology of fetal wound healing: collagen biosynthesis during dermal repair. | |
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MedLine Citation:
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PMID: 1403555 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rapid restoration of tissue integrity and breaking strength in healing fetal wounds is mainly a function of fetal wound collagen. In this study, the fetal and adult tissue responses to injury were characterized in terms of changes in collagen biosynthesis. Linear wounds and unwounded skin were incubated with radioactive proline, and collagen synthesis was measured as isotope incorporation into collagenase-sensitive protein. Likewise, noncollagen protein synthesis was represented by isotope incorporation into collagenase-resistant protein. Adult wounds demonstrated a preferential stimulation of collagen as compared with noncollagen protein synthesis after wounding. In contrast, both collagen and noncollagen protein synthesis were significantly elevated in the fetus during the first 5 days postwounding. Despite marked increases in fetal wound collagen synthesis above both unwounded fetal skin and adult wound levels, fetal wounds exhibited no evidence of excessive collagen deposition or scar formation after wounding. These findings suggest that the fetal response to tissue injury is a function of the distinctive qualities of fetal fibroblasts associated with the extracellular wound matrix and may involve rapid collagen turnover and degradation. |
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Authors:
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F W Frantz; R F Diegelmann; B A Mast; I K Cohen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of pediatric surgery Volume: 27 ISSN: 0022-3468 ISO Abbreviation: J. Pediatr. Surg. Publication Date: 1992 Aug |
Date Detail:
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Created Date: 1992-11-18 Completed Date: 1992-11-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0052631 Medline TA: J Pediatr Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 945-8; discussion 949 Citation Subset: IM |
Affiliation:
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Department of Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0117. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Collagen / biosynthesis* Fetus / physiology* Protein Biosynthesis Rabbits Wound Healing / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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GM 20298/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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