Document Detail


Biology and clinical applications of pancreatic cancer stem cells.
MedLine Citation:
PMID:  23622133     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pancreatic ductal adenocarcinomas comprise a hierarchy of tumor cells that develop around a population of cancer stem cells. The cancer stem cells promote tumor growth and progression through a number of mechanisms, including differentiation into bulk tumor cells, metastasis, alteration of adjacent stromal cells, and evasion of conventional therapies. As with other cancer stem cells, pancreatic cancer stem cells (PCSCs) can be distinguished from bulk tumor cells based on their expression of unique surface markers, abilities to form spheres under nonadherent conditions and tumors in mice, and self-renewal and differentiation capacities. We review the markers used to identify PCSCs, the signaling pathways that regulate PCSC functions, the complex interactions between PCSCs and stromal cells, and approaches to therapeutically target PCSCs and improve treatment of patients with pancreatic cancer.
Authors:
Ethan V Abel; Diane M Simeone
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  144     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-06-20     Revised Date:  2014-04-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1241-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / therapeutic use
Carcinoma, Pancreatic Ductal / metabolism*,  pathology,  therapy
Cell Communication
Cell Differentiation
Cell Proliferation
Humans
Molecular Targeted Therapy
Neoplastic Stem Cells / drug effects,  metabolism*,  pathology
Pancreatic Neoplasms / metabolism*,  pathology,  therapy
Signal Transduction
Stromal Cells / metabolism,  pathology
Tumor Markers, Biological / metabolism*
Tumor Microenvironment
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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