Document Detail

Biology of cholesteatoma: Special considerations in pediatric patients.
MedLine Citation:
PMID:  22264818     Owner:  NLM     Status:  Publisher    
Cholesteatoma is a unique pathologic condition of the temporal bone characterized by migration of keratinized squamous epithelium positioned into the middle ear and mastoid cavity. The exact pathogenic molecular mechanisms behind the formation and propagation of cholesteatoma remain unclear. This review will aim to define the classification of cholesteatomas, review the most accepted pathogenesis theories, describe the inherent molecular mechanisms dictating the hyperproliferative nature of cholesteatoma keratinocytes, and explore innate biological differences between pediatric and adult cholesteatoma.
Diego A Preciado
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-19
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  -     ISSN:  1872-8464     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Ireland Ltd.
Division of Pediatric Otolaryngology, Children's National Medical Center, George Washington University School of Medicine, 111 Michigan Av NW, Washington, DC 20010, United States.
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