Document Detail

Biology of bone cancer pain.
MedLine Citation:
PMID:  17062706     Owner:  NLM     Status:  MEDLINE    
Bone cancer pain is a devastating manifestation of metastatic cancer. Unfortunately, current therapies can be ineffective, and when they are effective, the duration of the patient's survival typically exceeds the duration of pain relief. New, mechanistically based therapies are desperately needed. Study of experimental animal models has provided insight into the mechanisms that drive bone cancer pain and provides an opportunity for developing targeted therapies. Mechanisms that drive bone cancer pain include tumor-directed osteoclast-mediated osteolysis, tumor cells themselves, tumor-induced nerve injury, stimulation of transient receptor potential vanilloid type 1 ion channel, endothelin A, and host cell production of nerve growth factor. Current and future therapies include external beam radiation, osteoclast-targeted inhibiting agents, anti-inflammatory drugs, transient receptor potential vanilloid type 1 antagonists, and antibody therapies that target nerve growth factor or tumor angiogenesis. It is likely that a combination of these therapies will be superior to any one therapy alone.
Michael J Goblirsch; Pawel P Zwolak; Denis R Clohisy
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  12     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-25     Completed Date:  2006-11-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6231s-6235s     Citation Subset:  IM    
Department of Orthopaedic Surgery, The University of Minnesota, Minneapolis, Minnesota 55455, USA.
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MeSH Terms
Bone Neoplasms / physiopathology*,  secondary*
Neoplasm Metastasis / physiopathology*
Pain / etiology*,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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