Document Detail

Biology of aortic aneurysms and dissections.
MedLine Citation:
PMID:  21979117     Owner:  NLM     Status:  MEDLINE    
The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predeterminants are influenced by smoking, hypertension, and atherosclerosis, and the result in an inflammatory response coupled to an accelerated proteolytic cascade that disrupts both elastin and collagen in the aortic wall.
Joseph S Fernandez-Moure; Daynene Vykoukal; Mark G Davies
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Methodist DeBakey cardiovascular journal     Volume:  7     ISSN:  1947-6108     ISO Abbreviation:  Methodist Debakey Cardiovasc J     Publication Date:    2011 Jul-Sep
Date Detail:
Created Date:  2011-10-07     Completed Date:  2012-07-16     Revised Date:  2012-08-17    
Medline Journal Info:
Nlm Unique ID:  101508600     Medline TA:  Methodist Debakey Cardiovasc J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2-7     Citation Subset:  IM    
Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, USA.
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MeSH Terms
Aneurysm, Dissecting / etiology,  genetics,  metabolism,  pathology*
Aorta / metabolism,  pathology*
Aortic Aneurysm / etiology,  genetics,  metabolism,  pathology*
Biological Markers / metabolism
Extracellular Matrix Proteins / metabolism
Genetic Predisposition to Disease
Oxidative Stress
Reactive Oxygen Species / metabolism
Risk Factors
Reg. No./Substance:
0/Biological Markers; 0/Extracellular Matrix Proteins; 0/Reactive Oxygen Species

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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