| Biology of the interleukin-9 pathway and its therapeutic potential for the treatment of asthma. | |
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MedLine Citation:
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PMID: 21428906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asthma is a complex disease characterized by variable airflow limitation, hyperresponsiveness, and airways inflammation. Despite valuable therapeutic advances to control asthma symptoms in the last decade, a quantifiable proportion of patients with moderate to severe asthma continue to experience inadequate disease control, highlighting an important unmet need. In animal models of asthma, interleukin (IL)-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways. Mast cells are involved in the pathogenesis of eosinophilic and noneosinophilic asthma. Thus, targeting the IL-9 pathway may provide a new therapeutic modality for asthma. The purpose of this review is to summarize the IL-9-mast cell axis in the pathogenesis of asthma and discuss clinical studies with a humanized anti-IL-9 monoclonal antibody, MEDI-528, in subjects with asthma. |
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Authors:
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Chad K Oh; Donald Raible; Gregory P Geba; Nestor A Molfino |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Inflammation & allergy drug targets Volume: 10 ISSN: 2212-4055 ISO Abbreviation: Inflamm Allergy Drug Targets Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-03 Completed Date: 2011-09-08 Revised Date: 2011-11-10 |
Medline Journal Info:
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Nlm Unique ID: 101266886 Medline TA: Inflamm Allergy Drug Targets Country: United Arab Emirates |
Other Details:
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Languages: eng Pagination: 180-6 Citation Subset: IM |
Affiliation:
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MedImmune, LLC, One MedImmune Way, Gaithersburg, MD 20878, USA. molfinon@medimmune.com. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibodies, Monoclonal / pharmacology Asthma / immunology*, physiopathology, therapy* Clinical Trials as Topic Disease Models, Animal Humans Immunotherapy* Interleukin-9 / antagonists & inhibitors, immunology* Mast Cells / immunology* Th1-Th2 Balance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Monoclonal; 0/Interleukin-9; 0/MEDI-528 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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