| Biology of Barrett's esophagus and esophageal adenocarcinoma. | |
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MedLine Citation:
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PMID: 21112495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The past few years have brought new advances in our understanding of the molecular mechanisms underlying the development of Barrett's esophagus and esophageal adenocarcinoma. Although knowledge of the genetic basis for these conditions has not yet translated into clinically useful biomarkers, the current pace of biomedical discovery holds endless possibilities for molecular medicine to improve the diagnosis and management of patients with these conditions. This article provides a useful conceptual basis for understanding the molecular events involved in the making of Barrett metaplasia and in its neoplastic progression, and provides a rationale for evaluating studies on the application of molecular medicine to the diagnosis and management of patients with Barrett's esophagus and esophageal adenocarcinoma. |
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Authors:
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David H Wang; Rhonda F Souza |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Gastrointestinal endoscopy clinics of North America Volume: 21 ISSN: 1558-1950 ISO Abbreviation: Gastrointest. Endosc. Clin. N. Am. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-11-29 Completed Date: 2011-04-01 Revised Date: 2012-01-04 |
Medline Journal Info:
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Nlm Unique ID: 9202792 Medline TA: Gastrointest Endosc Clin N Am Country: United States |
Other Details:
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Languages: eng Pagination: 25-38 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Inc. |
Affiliation:
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Department of Medicine, Veterans Affairs North Texas Health Care System, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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metabolism,
pathology* Barrett Esophagus / genetics, metabolism, pathology* Cell Transformation, Neoplastic* Esophageal Neoplasms / metabolism, pathology* Esophagitis / etiology Gastroesophageal Reflux / complications, physiopathology Humans Precancerous Conditions / genetics, metabolism, pathology* Signal Transduction |
| Grant Support | |
ID/Acronym/Agency:
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F32-CA123945/CA/NCI NIH HHS; R01 CA134571-01A1/CA/NCI NIH HHS; R01 DK063621-09/DK/NIDDK NIH HHS; R01-CA134571/CA/NCI NIH HHS; R01-DK63621/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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