Document Detail

Biologicals dramatic advances in the treatment of psoriasis.
MedLine Citation:
PMID:  16533166     Owner:  NLM     Status:  MEDLINE    
Innovations in biotechnology have made possible the development of several new systemic therapies for psoriasis - the "biologicals", a new group of compounds including monoclonal antibodies, fusion proteins and recombinant proteins. These novel biotechnological advances potentially offer designer drugs, which interfere with specific targets in the pathophysiological network of psoriasis and are thus much safer. The therapeutic strategy of biologicals is based on the knowledge derived from pathogenetic studies, which have focused on targeting disease relevant T-cell- or mediator-systems. Important targets include inactivation of soluble mediators such as tumor-necrosis-factor-alpha, the blockade of receptors for cytokines, adhesion molecules and the interference with T-cell activation by antigen-presenting cells. In addition, recombinant cytokines are able to modulate the immunological balance of this chronic inflammatory skin disease. Currently, up to forty agents are under investigation for the treatment of psoriasis. Four of these agents, alefacept, efalizumab, etanercept and infliximab have already impacted on routine clinical practice. Current developments in the treatment of psoriasis with biologicals are reviewed.
Dagmar Wilsmann-Theis; Saskia Martin; Michael Reber; Bartlomiej Kwiek; Thomas Bieber; Natalija Novak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  12     ISSN:  1381-6128     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2006  
Date Detail:
Created Date:  2006-03-14     Completed Date:  2007-03-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  989-99     Citation Subset:  IM    
Department of Dermatology, University of Bonn, Germany.
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MeSH Terms
Anti-Inflammatory Agents / pharmacology,  therapeutic use*
Antibodies, Monoclonal / pharmacology,  therapeutic use
Cell Adhesion
Clinical Trials as Topic
Immunologic Factors / pharmacology,  therapeutic use*
Interleukin-10 / pharmacology,  therapeutic use
Psoriasis / drug therapy*,  immunology
Recombinant Fusion Proteins / pharmacology,  therapeutic use
Recombinant Proteins / pharmacology,  therapeutic use
T-Lymphocytes / drug effects,  immunology
Tumor Necrosis Factor-alpha / antagonists & inhibitors,  immunology
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/IL10 protein, human; 0/Immunologic Factors; 0/Recombinant Fusion Proteins; 0/Recombinant Proteins; 0/Tumor Necrosis Factor-alpha; 0/efalizumab; 0/infliximab; 130068-27-8/Interleukin-10

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