Document Detail

Biologically based treatment approaches to the patient with resistant perinatal depression.
MedLine Citation:
PMID:  23828097     Owner:  NLM     Status:  Publisher    
This study aims to summarize the current state of knowledge regarding approaches to treatment-resistant depression in pregnancy and the postpartum period and to develop algorithms for ante- and postnatal management in cases of refractory major depression. PubMed, Scopus, Google Scholar, and the Cochrane Library databases were searched without temporal restriction. Search terms included pregnancy and depression, perinatal depression, postnatal depression, treatment resistance and depression, antipsychotics and pregnancy, antidepressants and pregnancy, and mood stabilizers and pregnancy. Abstracts were reviewed for relevance, and further articles were obtained from bibliographic citations. There is a significant subpopulation of patients in pregnancy and postpartum whose depressive symptoms do not respond to first-line treatments. No research studies have focused specifically on this population. Data extracted from studies on women with depressive symptoms in pregnancy suggest that in the absence of evidence on which to base clinical decisions, many are receiving combinations of psychotherapeutic medications that have not been specifically studied for use in pregnancy. Antidepressant use in pregnancy is well studied, but studies specifically addressing the case of the patient who does not respond to first-line treatments are absent. Research in this area is urgently needed. The authors review a number of possible therapeutic approaches to treatment-resistant depression in pregnancy and the postpartum period.
Thalia K Robakis; Katherine Ellie Williams
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-5
Journal Detail:
Title:  Archives of women's mental health     Volume:  -     ISSN:  1435-1102     ISO Abbreviation:  Arch Womens Ment Health     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815663     Medline TA:  Arch Womens Ment Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Psychiatry, Stanford University Medical Center, 401 Quarry Road, Stanford, CA, 94305, USA,
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