Document Detail

Biologically active peptides from Bothrops jararacussu venom.
MedLine Citation:
PMID:  1609644     Owner:  NLM     Status:  MEDLINE    
The venom of the Brazilian snake Bothrops jararacussu, was found to contain peptides capable of potentiating the smooth muscle contracting activity of bradykinin (BK). Chromatographic separation on Sephadex G-25 and Sephadex G-10 respectively, yielded an active peptide which at a concentration of 0.6 micrograms/ml doubled the effect of a single dose of BK on the isolated guinea-pig ileum. HPLC chromatography showed this material to contain one major and 4 minor components. The active peptide was 2-3 times more active than Captopril in the potentiation of the effects of BK on rat arterial blood pressure and on the isolated guinea pig ileum. It also showed marked capacity to inhibit angiotensin I-converting enzyme.
L A Ferreira; O B Henriques; I Lebrun; M B Batista; B C Prezoto; A S Andreoni; R Zelnik; G Habermehl
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Agents and actions. Supplements     Volume:  36     ISSN:  0379-0363     ISO Abbreviation:  Agents Actions Suppl.     Publication Date:  1992  
Date Detail:
Created Date:  1992-07-21     Completed Date:  1992-07-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7801014     Medline TA:  Agents Actions Suppl     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
Instituto Butantan, São Paulo, Brazil.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Blood Pressure / drug effects
Bradykinin / pharmacology
Crotalid Venoms / chemistry,  pharmacology*
Freeze Drying
Guinea Pigs
Ileum / drug effects
Molecular Weight
Muscle Contraction / drug effects
Muscle, Smooth / drug effects
Peptides / isolation & purification,  pharmacology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Crotalid Venoms; 0/Peptides; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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