Document Detail


Biological versatility of crotamine - a cationic peptide from the venom of a South American rattlesnake.
MedLine Citation:
PMID:  21062230     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
IMPORTANCE OF THE FIELD: Molecules isolated from animals, insects, plants or microorganisms can provide prototypes for design of biopharmaceutical products. Some venom toxins and their derivatives are used in medicine, while others provide templates for development of new drugs.
AREAS COVERED IN THIS REVIEW: The mild toxin, crotamine, a small basic low-molecular-weight polypeptide purified from the venom of a South American rattlesnake, Crotalus durissus terrificus. Crotamine was discovered more than 50 years ago and only in the past six years has its exceptional biological versatility been demonstrated. Particularly, its cell-penetrating ability, which allows crotamine to cross cell membranes and to accumulate in the nucleus; its use for intracellular vesicle tracking and as a cell cycle marker and its capability for delivering DNA into replicating mammalian cells. Both antimicrobial action and potential selective antitumor activity of crotamine have also been found.
WHAT THE READER WILL GAIN: Multidisciplinary approaches and pathways of discovery placed crotamine in a rare category of versatile biomolecules, in which concentration, molecular target preference, structural ancestry and specificity toward biological membranes play an integral role.
TAKE HOME MESSAGE: Crotamine is a druggable peptide with high potential for use as an imaging agent for detecting dividing cells, for intracellular delivery of hydrophilic biomolecules, and as an alternative chemotherapeutic compound against aggressive types of cancer.
Authors:
Irina Kerkis; Fernando de Sá Silva; Alexandre Pereira; Alexandre Kerkis; Gandhi Rádis-Baptista
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-10
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  19     ISSN:  1744-7658     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  1515-25     Citation Subset:  IM    
Affiliation:
Laboratório de Genética e Laboratório Especial de Toxinologia Aplicada - CAT/CEPID do Instituto Butantan, Av. Vital Brazil 1500, 05503-900, São Paulo, SP, Brasil. ikerkis@butantan.gov.br
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