Document Detail


Biological variations in hyperlipidemic children and adolescents treated with fenofibrate.
MedLine Citation:
PMID:  6113065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Beside their pharmacological action drugs may have unexpected side effects which must be known and taken into account in the interpretation of laboratory tests. In this work, we followed 17 hyperlipidemic subjects, aged 4-19 years, treated with fenofibrate only. We performed several plasma tests before and during treatment. The hypolipidemic action of fenofibrate was evident: decreases of cholesterol and triglycerides mean values were, respectively, 22% and 39% after 3 months of treatment. Other plasma constituents were also significantly decreased: uric acid, 20%; bilirubin, 19%; alkaline phosphatases, 15%. The aminotransferase activities (both AST and ALT) were increased in only four subjects after 3 months. The highest values were 88 U/l for AST and 109 U/l for ALT (the initial values were, respectively, 28 U/l and 23 U/l). These activities decreased when the treatment was stopped. These variations were isolated and transient.
Authors:
J Steinmetz; C Morin; E Panek; G Siest; P Drouin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  112     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43=53     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Alkaline Phosphatase / blood
Antilipemic Agents / therapeutic use*
Bilirubin / blood
Child
Child, Preschool
Cholesterol / blood
Humans
Hyperlipidemias / blood*,  drug therapy
Lipoproteins, LDL / blood
Procetofen / analogs & derivatives,  therapeutic use*
Propionates / therapeutic use*
Transaminases / blood
Triglycerides / blood
Uric Acid / blood
gamma-Glutamyltransferase / blood
Chemical
Reg. No./Substance:
0/Antilipemic Agents; 0/Lipoproteins, LDL; 0/Propionates; 0/Triglycerides; 26129-32-8/fenofibric acid; 49562-28-9/Procetofen; 57-88-5/Cholesterol; 635-65-4/Bilirubin; 69-93-2/Uric Acid; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.-/Transaminases; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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