Document Detail

Biological variations in hyperlipidemic children and adolescents treated with fenofibrate.
MedLine Citation:
PMID:  6113065     Owner:  NLM     Status:  MEDLINE    
Beside their pharmacological action drugs may have unexpected side effects which must be known and taken into account in the interpretation of laboratory tests. In this work, we followed 17 hyperlipidemic subjects, aged 4-19 years, treated with fenofibrate only. We performed several plasma tests before and during treatment. The hypolipidemic action of fenofibrate was evident: decreases of cholesterol and triglycerides mean values were, respectively, 22% and 39% after 3 months of treatment. Other plasma constituents were also significantly decreased: uric acid, 20%; bilirubin, 19%; alkaline phosphatases, 15%. The aminotransferase activities (both AST and ALT) were increased in only four subjects after 3 months. The highest values were 88 U/l for AST and 109 U/l for ALT (the initial values were, respectively, 28 U/l and 23 U/l). These activities decreased when the treatment was stopped. These variations were isolated and transient.
J Steinmetz; C Morin; E Panek; G Siest; P Drouin
Related Documents :
17853285 - Serum markers of brain-cell damage and c-reactive protein are unaffected by electroconv...
7560745 - Serum biochemical and histopathological changes related to the hepatic function in pigs...
15013185 - Evaluation of hepatoprotective effect of amalkadi ghrita against carbon tetrachloride-i...
2874955 - Hepatotoxic effects of ccl4 on english sole (parophrys vetulus): possible indicators of...
12005285 - Oral magnesium load test in patients with migraine.
3429065 - Plasma protein binding of dicloxacillin: effects of age and diseases.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  112     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43=53     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alkaline Phosphatase / blood
Antilipemic Agents / therapeutic use*
Bilirubin / blood
Child, Preschool
Cholesterol / blood
Hyperlipidemias / blood*,  drug therapy
Lipoproteins, LDL / blood
Procetofen / analogs & derivatives,  therapeutic use*
Propionates / therapeutic use*
Transaminases / blood
Triglycerides / blood
Uric Acid / blood
gamma-Glutamyltransferase / blood
Reg. No./Substance:
0/Antilipemic Agents; 0/Lipoproteins, LDL; 0/Propionates; 0/Triglycerides; 26129-32-8/fenofibric acid; 49562-28-9/Procetofen; 57-88-5/Cholesterol; 635-65-4/Bilirubin; 69-93-2/Uric Acid; EC; EC 2.6.1.-/Transaminases; EC Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Gamma-glutamyltransferases in bile and sera from patients with extrahepatic biliary obstruction.
Next Document:  Urinary excretion of N-acetyl-beta-D-glucosaminidase and alanine aminopeptidase in patients receivin...