| Biological significance of tumor budding at the invasive front of human colorectal carcinoma cells. | |
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MedLine Citation:
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PMID: 22569829 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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At the invasive front of colorectal carcinoma (CRC), the existence of tumor budding (TB), the detachment and migration of small clusters of tumor cells from the neoplastic epithelium, correlates with high incidence of local invasion and distant metastasis; however, the molecular background of TB is still unknown. In human CRC-derived SW480 cells, CD133+ cells showed cancer stem cell (CSC)-like properties, high tumorigenicity and pluripotency. By a comparative study of gene expression between CD133+ and CD133- SW480 cells, high sensitivity against transforming growth factor-β (TGF-β) was suggested in CD133+ SW480 cells. Interestingly, treatment with recombinant TGF-β1 increased the numbers of cells expressing CD133 and SNAI1. Furthermore, in CD133- SW480 cells, the SNAI1-induced epithelial-mesenchymal transition (EMT) restored the population of CD133+ cells and increased tumorigenicity, cell motility/invasiveness and matrix metalloproteinase 2 (MMP2) expression. In stage II CRC tissues, TB was asso-ciated with increased levels of SNAI1 expression as well as high incidence of metachronous lymph node metastasis post-surgical resection. These findings suggest that TGF-β regulates not only the induction of EMT but also the restoration of CSCs in CRC. The tumor microenvironment at the invasive front is important for the formation of tumor buds in CRC. |
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Authors:
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Yusra; Shuho Semba; Hiroshi Yokozaki |
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Publication Detail:
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Type: Journal Article Date: 2012-05-02 |
Journal Detail:
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Title: International journal of oncology Volume: 41 ISSN: 1791-2423 ISO Abbreviation: Int. J. Oncol. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-05-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: Greece |
Other Details:
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Languages: eng Pagination: 201-10 Citation Subset: IM |
Affiliation:
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Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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