Document Detail


Biological properties of trabecular meshwork cells.
MedLine Citation:
PMID:  18789927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The molecular and physiological mechanisms that lead to the progression of glaucoma are poorly understood. Despite the fact that glaucoma afflicts millions of people worldwide, research on the disease is limited by the current animal models that do not translate well to human forms of the disease. However, recent advances in culturing and manipulating human trabecular meshwork cells may provide a means to elucidate some of the mechanisms that cause glaucoma. This review focuses on the properties of trabecular meshwork cells, from their characteristic expression profile in vivo to their responsiveness to biochemical and biophysical signals in vitro. Hopefully the study of cultured trabecular meshwork cells will provide a better understanding of glaucoma and lead to new, much needed therapies.
Authors:
Joshua Z Gasiorowski; Paul Russell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2008-08-26
Journal Detail:
Title:  Experimental eye research     Volume:  88     ISSN:  1096-0007     ISO Abbreviation:  Exp. Eye Res.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-06-22     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0370707     Medline TA:  Exp Eye Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  671-5     Citation Subset:  IM    
Affiliation:
School of Veterinary Medicine, University of Wisconsin-Madison, Department of Surgical Sciences, Madison, WI 53706, USA.
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MeSH Terms
Descriptor/Qualifier:
Cell Culture Techniques
Dexamethasone / pharmacology
Glaucoma / pathology
Glucocorticoids / pharmacology
Humans
Mechanotransduction, Cellular / physiology
Models, Biological
Oxidative Stress / physiology
Phagocytosis
Trabecular Meshwork / cytology*,  drug effects
Transforming Growth Factor beta / pharmacology
Grant Support
ID/Acronym/Agency:
1R01EY016134-01A1/EY/NEI NIH HHS; 5R01HL079012-02/HL/NHLBI NIH HHS; R01 EY016134/EY/NEI NIH HHS; R01 HL079012/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Transforming Growth Factor beta; 50-02-2/Dexamethasone
Comments/Corrections

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