Document Detail


Biological & physiological aspects of action of insulin-like growth factor peptide family.
MedLine Citation:
PMID:  17598937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The insulin-like growth factor (IGF) is a complex system of peptide hormones (insulin-like growth factors of type 1 and 2, IGF-1 and IGF-2), cell surface receptors (insulin receptor, IR; insulin-like growth factor receptors of type 1 and 2, IGF-R1, IGF-R2) and circulating binding proteins (insulinlike growth factor binding proteins, IGF-BP 1-6). IGF-1 and -2 are mitogens that play a role in regulating cell proliferation, differentiation and apoptosis. Their effects are mediated through the IGF-R1 which initiates signaling cascades that result in regulation of a number of biological responses. IGF-R2, together with IGF-BPs is involved in binding, internalization and degradation of IGF-2. IGF proteins regulate cell proliferation in an interconnected action via autocrine, paracrine and endocrine regulatory mechanisms. Consequently, any perturbation in each level of the IGF signaling proteins has been shown to be implicated in development and progression of numerous cancer types. The most important single components in this processes are IGF ligands as well as IGF-R1 - when disturbed they act as oncogenes. It has been shown that: (i) high serum concentrations of IGF-1 and IGF-2 are associated with an increased risk of breast, prostate, colorectal and lung cancers; and (ii) IGF-R1 is commonly disturbed in many tumours (like gastric, lung, endometrial cancer) leading to a phenotype of anchorage-independent tumour growth. In contrast, IGF-R2 is considered to act as a tumour suppressor gene; it protects the cells from neoplastic impulses. Consistent with the IGFs autocrine/paracrine regulation of tumour growth, cancer treatment strategies interfering with IGF-R1 signaling have been developed, that may be useful in future diagnostic and therapeutic strategies.
Authors:
Jasminka Pavelić; Tanja Matijević; Jelena Knezević
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Indian journal of medical research     Volume:  125     ISSN:  0971-5916     ISO Abbreviation:  Indian J. Med. Res.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-06-29     Completed Date:  2007-10-15     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  0374701     Medline TA:  Indian J Med Res     Country:  India    
Other Details:
Languages:  eng     Pagination:  511-22     Citation Subset:  IM    
Affiliation:
Rudjer Bosković Institute, Division of Molecular Medicine, Bijenicka 54, 10002 Zagreb, Croatia. jpavelic@irb.hr
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MeSH Terms
Descriptor/Qualifier:
Animals
Growth Hormone / metabolism
Humans
Insulin / genetics,  metabolism
Insulin-Like Growth Factor Binding Proteins / genetics,  metabolism
Neoplasms / metabolism
Receptors, Somatomedin / genetics,  metabolism*
Signal Transduction / physiology
Somatomedins / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Insulin; 0/Insulin-Like Growth Factor Binding Proteins; 0/Receptors, Somatomedin; 0/Somatomedins; 9002-72-6/Growth Hormone

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