Document Detail


Biological and pharmaceutical factors affecting the absorption and lymphatic delivery of ciclosporin A from gastrointestinal tract.
MedLine Citation:
PMID:  3379567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Absorption site and some biological and pharmaceutical factors affecting the absorption and transport of ciclosporin A (CiA) from the gastrointestinal (GI) tract into both the thoracic lymphatics and the systemic circulation have been studied in rats. In a group of rats whose gastric emptying of orally administered CiA in HCO-60 formulation, 7.0 mg/kg, was physically prevented, both the lymphatic and the systemic availabilities of CiA were negligibly low. CiA was orally administered to another group of rats whose major intestinal lymphatics as well as thoracic lymph ducts were cannulated, and it was revealed that the amount of CiA delivered to the major intestinal lymphatics was about six times greater than that of CiA transferred into the thoracic lymphatics. In bile fistulous rats, the systemic availability of CiA was predominantly decreased but the lymphatic availability was not so decreased. In contrast, solvents such as propylene glycol and polyethylene glycol affected both the systemic and the lymphatic availabilities of CiA, which were also dependent on the absorption site. In particular, the lower small intestine does not contribute to the lymphatic availability of CiA.
Authors:
K Takada; Y Furuya; H Yoshikawa; S Muranishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacobio-dynamics     Volume:  11     ISSN:  0386-846X     ISO Abbreviation:  J. Pharmacobio-dyn.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-07-25     Completed Date:  1988-07-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7901854     Medline TA:  J Pharmacobiodyn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  80-7     Citation Subset:  IM    
Affiliation:
Department of Biopharmaceutics, Kyoto Pharmaceutical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Bile / metabolism
Biological Availability
Biological Transport / drug effects
Castor Oil / administration & dosage,  analogs & derivatives
Cyclosporins / administration & dosage,  pharmacokinetics*
Digestive System / metabolism*
Intestinal Absorption
Lymphatic System / metabolism*
Male
Rats
Rats, Inbred Strains
Thoracic Duct / metabolism
Vehicles
Chemical
Reg. No./Substance:
0/Cyclosporins; 0/Vehicles; 61791-12-6/polyethoxylated castor oil; 8001-79-4/Castor Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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