Document Detail

Biological pathways to bladder carcinogenesis.
MedLine Citation:
PMID:  11101088     Owner:  NLM     Status:  MEDLINE    
The transformation of normal urothelium into histologically different neoplastic states has been well characterized, and current clinical management of both superficial and invasive bladder cancer has benefited from recent scientific discoveries. The ability to define novel treatment strategies including surgical, chemotherapeutic, and gene therapies relies on our understanding of the basic mechanisms underlying human bladder carcinogenesis. Many in vitro culture systems and in vivo animal models have been developed over recent years, which have been used to define key molecular events that are associated with the development of bladder cancer. The biological pathways through which normal urothelium may progress to superficial or invasive disease will be discussed in the framework of recent advances in the field.
M L Gonzalgo; M P Schoenberg; R Rodriguez
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in urologic oncology     Volume:  18     ISSN:  1081-0943     ISO Abbreviation:  Semin. Urol. Oncol.     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-21     Completed Date:  2001-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9514993     Medline TA:  Semin Urol Oncol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  256-63     Citation Subset:  IM    
Department of Urology, The James Buchanan Brady Urological Institute, Baltimore, MD 21287, USA.
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MeSH Terms
Urinary Bladder / pathology
Urinary Bladder Neoplasms / etiology*,  genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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