Document Detail


Biological monitoring of workers exposed to N,N-dimethylformamide by determination of the urinary metabolites, N-methylformamide and N-acetyl-S-(N-methylcarbamoyl) cysteine.
MedLine Citation:
PMID:  7672856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Biological monitoring of workers exposed to N,N-dimethylformamide (DMF) was carried out by determination of the urinary metabolites, N-methylformamide (MF, mainly from N-hydroxymethylformamide) and N-acetyl-S-(N-methylcarbamoyl)cysteine (AMCC), which were derived from two different routes of metabolism of the solvent. The urinary levels of MF increased rapidly at the start of the work shift, and decreased almost to zero within 24 h after the beginning of the last exposure. The highest level was found between the end of the afternoon shift and bedtime. AMCC levels remained constant over the consecutive work days and increased after the cessation of exposure, with the peak concentration being observed at 16-40 h after the cessation of exposure. AMCC levels at the beginning of the next morning shift were closely correlated with personal exposure levels of DMF in air, although the correlation of MF and DMF in air was highest in the urine at the end of the shift. Hence urinary AMCC represents an index of the average exposure during several preceding work days and may indicate the internal dose. By contrast, MF represents an index of daily exposure.
Authors:
T Sakai; H Kageyama; T Araki; T Yosida; T Kuribayashi; Y Masuyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of occupational and environmental health     Volume:  67     ISSN:  0340-0131     ISO Abbreviation:  Int Arch Occup Environ Health     Publication Date:  1995  
Date Detail:
Created Date:  1995-10-13     Completed Date:  1995-10-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7512134     Medline TA:  Int Arch Occup Environ Health     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Affiliation:
Center of Occupational Medicine, Tokyo Labor Accident Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / analogs & derivatives,  urine*
Air Pollutants, Occupational / analysis,  metabolism*
Body Burden
Dimethylformamide / analogs & derivatives,  analysis,  metabolism*
Environmental Monitoring / methods*
Humans
Liver / metabolism
Male
Maximum Allowable Concentration
Time Factors
Chemical
Reg. No./Substance:
0/Air Pollutants, Occupational; 616-91-1/Acetylcysteine; 68-12-2/Dimethylformamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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