Document Detail


Biological monitoring of pesticide exposure: a review of analytical methods.
MedLine Citation:
PMID:  11996486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A wide range of studies concerned with analytical methods for biological monitoring of exposure to pesticides is reviewed. All phases of analytical procedures are assessed, including sampling and storage, sample preparation and analysis, and validation of methods. Most of the studies aimed at measuring metabolites or unchanged compounds in urine and/or blood as biological indicators of exposure or dose. Biological indicators of effect, such as cholinesterase, are also evaluated. The principal groups of pesticides are considered: organophosphorus pesticides, carbamate pesticides, organochlorine pesticides, pyrethroid pesticides, herbicides, fungicides and other compounds. Choice of the method for biological monitoring of exposure depends on the study population: a detection limit of 1 microg/l or less is required for the general population; higher values are adequate for occupationally exposed subjects. Interpretation of results is also discussed. Since biological indices of exposure are only available for a few compounds, biological reference values, established for the general population, may be used for comparison with levels of professionally exposed subjects.
Authors:
Cristina Aprea; Claudio Colosio; Teresa Mammone; Claudio Minoia; Marco Maroni
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences     Volume:  769     ISSN:  1570-0232     ISO Abbreviation:  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-08     Completed Date:  2002-11-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101139554     Medline TA:  J Chromatogr B Analyt Technol Biomed Life Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-219     Citation Subset:  IM    
Affiliation:
Department of Occupational Toxicology and Industrial Hygiene, National Health Service, Siena, Italy. maaprea@tin.it
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MeSH Terms
Descriptor/Qualifier:
Environmental Monitoring / methods*
Pesticides / analysis*,  classification
Chemical
Reg. No./Substance:
0/Pesticides

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